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Literature summary for 2.4.2.30 extracted from

  • Tiemann, B.; Depping, R.; Gineikiene, E.; Kaliniene, L.; Nivinskas, R.; Rueger, W.
    ModA and ModB, two ADP-ribosyltransferases encoded by bacteriophage T4: Catalytic properties and mutation analysis (2004), J. Bacteriol., 186, 7262-7272.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Tequatrovirus T4

Protein Variants

Protein Variants Comment Organism
E118A mutation reduces the toxicity of the enzyme and still allows small colonies to grow Tequatrovirus T4
E163A mutation reduces toxicity of ModA to a minor extent Tequatrovirus T4
E165A mutation in ModA reduces the toxicity to colony growth Tequatrovirus T4
E171A mutation reduces the toxicity of the enzyme and still allows small colonies to grow Tequatrovirus T4
E173A mutation largly abolishes enzyme activity Tequatrovirus T4
F127A mutation in ModA reduces the toxicity to colony growth Tequatrovirus T4
F129A mutation in ModA reduces the toxicity to colony growth Tequatrovirus T4
F129A mutation largly abolishes enzyme activity Tequatrovirus T4
I176A mutation reduces the toxicity of the enzyme and still allows small colonies to grow Tequatrovirus T4
L71A mutation largly abolishes enzyme activity Tequatrovirus T4
N128A mutation reduces toxicity of ModA to a minor extent Tequatrovirus T4
N130A mutant enzyme with toxicity close to that of wild-type enzyme Tequatrovirus T4
Q116A mutation reduces toxicity of ModA to a minor extent Tequatrovirus T4
Q164A mutation reduces toxicity of ModA to a minor extent Tequatrovirus T4
Q172A mutant enzyme with toxicity close to that of wild-type enzyme Tequatrovirus T4
R72A mutation in ModA reduces the toxicity to colony growth Tequatrovirus T4
R73A mutation largly abolishes enzyme activity Tequatrovirus T4
S109A mutation in ModA reduces the toxicity to colony growth Tequatrovirus T4
S111A mutant enzyme with toxicity close to that of wild-type enzyme Tequatrovirus T4
Y131A mutation largly abolishes enzyme activity Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + RNA polymerase Tequatrovirus T4 three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
?
NAD+ + RNA polymerase Tequatrovirus T4 ModA three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
?
NAD+ + RNA polymerase Tequatrovirus T4 ModB three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
?

Organism

Organism UniProt Comment Textmining
Tequatrovirus T4 P12726 ModA
-
Tequatrovirus T4 P12726 ModB
-
Tequatrovirus T4 ModA P12726 ModA
-
Tequatrovirus T4 ModB P12726 ModB
-

Purification (Commentary)

Purification (Comment) Organism
-
Tequatrovirus T4

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + RNA polymerase
-
Tequatrovirus T4 nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
?
NAD+ + RNA polymerase three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control Tequatrovirus T4 nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
?
NAD+ + RNA polymerase
-
Tequatrovirus T4 ModA nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
?
NAD+ + RNA polymerase three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control Tequatrovirus T4 ModA nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
?
NAD+ + RNA polymerase
-
Tequatrovirus T4 ModB nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
?
NAD+ + RNA polymerase three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control Tequatrovirus T4 ModB nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
?

Synonyms

Synonyms Comment Organism
ModA
-
Tequatrovirus T4
ModB
-
Tequatrovirus T4