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Literature summary for 2.4.2.30 extracted from

  • DiNovo, A.A.; Schey, K.L.; Vachon, W.S.; McGuffie, E.M.; Olson, J.C.; Vincent, T.S.
    ADP-ribosylation of cyclophilin A by Pseudomonas aeruginosa exoenzyme S (2006), Biochemistry, 45, 4664-4673.
    View publication on PubMed
Search for more literature for 2.4.2.30

Protein Variants

Protein Variants Comment Organism
additional information construction of an enzyme-deficient strain 388DELTAexoS Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + cyclophilin A Pseudomonas aeruginosa cytosolic protein of several human epithelial cells, modification at Arg55 and Arg69 of cyclophilin A, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, overview nicotinamide + (ADP-D-ribosyl)-cyclophilin A
-
 ?
NAD+ + cyclophilin A Pseudomonas aeruginosa 388 cytosolic protein of several human epithelial cells, modification at Arg55 and Arg69 of cyclophilin A, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, overview nicotinamide + (ADP-D-ribosyl)-cyclophilin A
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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-
-
Pseudomonas aeruginosa 388
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information exoenzyme S is a bifunctional type III secretion, TTS, effector protein, with GTPase-activating and ADP-ribosyltransferase activities Pseudomonas aeruginosa ?
-
 ?
additional information exoenzyme S is a bifunctional type III secretion, TTS, effector protein, with GTPase-activating and ADP-ribosyltransferase activities Pseudomonas aeruginosa 388 ?
-
 ?
NAD+ + cyclophilin A cytosolic protein of several human epithelial cells, modification at Arg55 and Arg69 of cyclophilin A, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, overview Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)-cyclophilin A
-
 ?
NAD+ + cyclophilin A a non-G-protein substrate with peptidyl-prolyl isomerase activity, from several human epithelial cells, modification at Arg55 and Arg69, but not at Arg148, of cyclophilin A, i.e. CpA, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, activity with CpA mutants, overview Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)-cyclophilin A
-
 ?
NAD+ + cyclophilin A cytosolic protein of several human epithelial cells, modification at Arg55 and Arg69 of cyclophilin A, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, overview Pseudomonas aeruginosa 388 nicotinamide + (ADP-D-ribosyl)-cyclophilin A
-
 ?
NAD+ + cyclophilin A a non-G-protein substrate with peptidyl-prolyl isomerase activity, from several human epithelial cells, modification at Arg55 and Arg69, but not at Arg148, of cyclophilin A, i.e. CpA, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, activity with CpA mutants, overview Pseudomonas aeruginosa 388 nicotinamide + (ADP-D-ribosyl)-cyclophilin A
-
 ?

Synonyms

Synonyms Comment Organism
ADP-ribosyltransferase
-
 Pseudomonas aeruginosa
ADPRT
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 Pseudomonas aeruginosa
exoenzyme S
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 Pseudomonas aeruginosa
ExoS
-
 Pseudomonas aeruginosa
TTS-ExoS
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 Pseudomonas aeruginosa