Crystallization (Comment) | Organism |
---|---|
- |
Escherichia coli |
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(8-phosphonooctyl)-6-amino-5-bromouracil | competitive | Homo sapiens | |
1-(8-phosphonooctyl)-7-deazaxanthine | competitive | Homo sapiens | |
5-bromo-6-aminouracil | - |
Homo sapiens | |
5-chloro-6-[1-(imminopyrrolidinyl)methyl]uracil hydrochloride | i.e. TPI, competitive | Homo sapiens | |
6-(4-phenlybutylamino)uracil | PBAU, 50% inhibition at 0.03 mM | Homo sapiens | |
6-aminothymine | - |
Homo sapiens | |
7-deazaxanthine | competitive, 50% inhibition at 0.04 mM | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
2 * 45000 | Homo sapiens |
90000 | - |
- |
Escherichia coli |
90000 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | role in thymidine metabolism, homeostasis, development and regeneration of central nervous system and formation of blood/brain barrier | ? | - |
? | |
additional information | Homo sapiens | angiogenic activity | ? | - |
? | |
thymine + 2-deoxy-D-ribose 1-phosphate | Escherichia coli | - |
thymidine + phosphate | - |
? | |
thymine + 2-deoxy-D-ribose 1-phosphate | Homo sapiens | enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts | thymidine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
homogeneity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
breast | tumor specimen | Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
gastrointestinal cancer cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
additional information | no activity in normal brain | Homo sapiens | - |
ovarian cancer cell | malignant tissue | Homo sapiens | - |
pancreatic cancer cell | - |
Homo sapiens | - |
renal cell carcinoma cell | - |
Homo sapiens | - |
stomach | ulcer | Homo sapiens | - |
uterus | leiomyoma | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-(tetrahydro-2-furanyl)-5-fluorouracil + phosphate | i.e. Tegafur | Homo sapiens | ? | - |
? | |
5'-deoxy-5-fluorouridine + phosphate | - |
Homo sapiens | 5-fluorouracil + 5-deoxyribose-1-phosphate | - |
? | |
additional information | role in thymidine metabolism, homeostasis, development and regeneration of central nervous system and formation of blood/brain barrier | Homo sapiens | ? | - |
? | |
additional information | angiogenic activity | Homo sapiens | ? | - |
? | |
thymidine + phosphate | - |
Escherichia coli | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
thymidine + phosphate | enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts | Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
thymine + 2-deoxy-D-ribose 1-phosphate | - |
Escherichia coli | thymidine + phosphate | - |
? | |
thymine + 2-deoxy-D-ribose 1-phosphate | enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts | Homo sapiens | thymidine + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Escherichia coli |
dimer | 2 * 45000 | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00002 | - |
5-chloro-6-[1-(imminopyrrolidinyl)methyl]uracil hydrochloride | - |
Homo sapiens |