Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl]uracil hydrochloride | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.5 | - |
thymidine | in 50 mM phosphate buffer, pH 6.8 | Escherichia coli | |
10 | - |
3'-Deoxythymidine | in 50 mM phosphate buffer, pH 6.8 | Escherichia coli | |
32 | - |
5'-Deoxythymidine | in 50 mM phosphate buffer, pH 6.8 | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione + phosphate | 56% conversion after one h | Escherichia coli | ? | - |
? | |
1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate | 11% conversion after one h | Escherichia coli | ? | - |
? | |
1-[(2R,4S,5R)-5-(hydroxymethyl)-4-sulfanyltetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate | 0.76% conversion after one h | Escherichia coli | ? | - |
? | |
1-[(2R,4S,5S)-4-hydroxy-5-(sulfanylmethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate | 39% conversion after one h | Escherichia coli | ? | - |
? | |
1-[(2R,4S,5S)-5-(chloromethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate | 24% conversion after one h | Escherichia coli | ? | - |
? | |
3'-deoxythymidine + phosphate | 3.2% conversion after one h | Escherichia coli | thymine + 2,3-dideoxy-D-ribose 1-phosphate | - |
? | |
3'-thiothymidine + phosphate | 0.76% conversion after 1 h | Escherichia coli | thymine + 3-thio-2,3-dideoxy-D-ribose 1-phosphate | - |
? | |
4'-thiothymidine + phosphate | 3.8% conversion after one h | Escherichia coli | ? | - |
? | |
5'-amino-5'-deoxythymidine + phosphate | 11% conversion after 1 h | Escherichia coli | thymine + 5-amino-2,5-dideoxy-D-ribose 1-phosphate | - |
? | |
5'-chloro-5'-deoxythymidine + phosphate | 24% conversion after 1 h | Escherichia coli | thymine + 5-chloro-2,5-dideoxy-D-ribose 1-phosphate | - |
? | |
5'-deoxythymidine + phosphate | 68% conversion after one h | Escherichia coli | thymine + 2,5-dideoxy-D-ribose 1-phosphate | - |
? | |
5'-thiothymidine + phosphate | 39% conversion after 1 h | Escherichia coli | thymine + 5-thio-2,5-dideoxy-D-ribose 1-phosphate | - |
? | |
6-azathymidine + phosphate | 5.4% conversion after one h | Escherichia coli | uracil + deoxyribose-1-phosphate | - |
? | |
additional information | no activity with 3'beta-thymidine, 4'-thio-1'-alpha-thymidine, 1-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]thymine, 5-methyl-2-pyrimidinone nucleoside, and deoxycytidine | Escherichia coli | ? | - |
? | |
thymidine + phosphate | 86% conversion after one h | Escherichia coli | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
uracil + phosphate | 88% conversion after one h | Escherichia coli | uracil + ribose 1-phosphate | - |
? | |
uridine + phosphate | 56% conversion after 1 h | Escherichia coli | uracil + D-ribose 1-phosphate | - |
? |