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BRENDA support

Literature summary for 2.4.2.4 extracted from

  • Bartsch, R.; Steger, G.G.; Forstner, B.; Wenzel, C.; Pluschnig, U.; Rizovski, B.; Altorjai, G.; Zielinski, C.C.; Mader, R.M.
    Expression of thymidine phosphorylase in peripheral blood cells of breast cancer patients is not increased by paclitaxel (2007), BMC Clin. Pharmacol., 7, 7-7.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.4

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation of protein expression by paclitaxel, therefore no increased haematotoxicity due to thymidine phosphorylase upregulation is expected from the combination of taxanes and capecitabine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?