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Literature summary for 2.4.2.4 extracted from

  • Pula, G.; Mayr, U.; Evans, C.; Prokopi, M.; Vara, D.S.; Yin, X.; Astroulakis, Z.; Xiao, Q.; Hill, J.; Xu, Q.; Mayr, M.
    Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures (2009), Circ. Res., 104, 32-40.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information gene silencing results in a significant increase in basal and oxidative stress-induced apoptosis, the effect is abrogated by supplementation with 2-deoxy-D-ribose-1-phosphate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-bromo-6-amino-uracil enzyme inhibition results in a significant increase in basal and oxidative stress-induced apoptosis, the effect is abrogated by supplementation with 2-deoxy-D-ribose-1-phosphate Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymidine + phosphate Homo sapiens
-
thymine + 2-deoxy-alpha-D-ribose 1-phosphate 2-deoxy-alpha-D-ribose 1-phosphate strongly promoted neovascularization ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
Homo sapiens
-
mononuclear cell from peripheral blood Homo sapiens
-
additional information enzyme expression analysis in cell and tissues, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymidine + phosphate
-
Homo sapiens thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?
thymidine + phosphate
-
Homo sapiens thymine + 2-deoxy-alpha-D-ribose 1-phosphate 2-deoxy-alpha-D-ribose 1-phosphate strongly promoted neovascularization ?

General Information

General Information Comment Organism
physiological function thymidine phosphorylase is a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures, overview. The enzyme is a survival factor, it protects against apoptosis, stimulates endothelial cell migration and enhances wound healing in vitro and angiogenesis in vivo, overview Homo sapiens