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Literature summary for 2.4.2.8 extracted from

  • Karnawat, V.; Gogia, S.; Balaram, H.; Puranik, M.
    Differential distortion of purine substrates by human and Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase to catalyse the formation of mononucleotides (2015), ChemPhysChem, 16, 2172-2181.
    View publication on PubMed
Search for more literature for 2.4.2.8

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Homo sapiens
Mg2+ dependent on Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
guanine + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 GMP + diphosphate
-
 r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate Plasmodium falciparum
-
 GMP + diphosphate
-
 r
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 IMP + diphosphate
-
 r
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate Plasmodium falciparum
-
 IMP + diphosphate
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P00492
-
-
Plasmodium falciparum P20035
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens GMP + diphosphate
-
 r
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium falciparum GMP + diphosphate
-
 r
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens IMP + diphosphate
-
 r
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium falciparum IMP + diphosphate
-
 r

Synonyms

Synonyms Comment Organism
HGPRT
-
 Homo sapiens
HGPRT
-
 Plasmodium falciparum
hypoxanthine-guanine phosphoribosyltransferase
-
 Homo sapiens
hypoxanthine-guanine phosphoribosyltransferase
-
 Plasmodium falciparum