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Literature summary for 2.4.2.9 extracted from

  • Arsene-Ploetze, F.; Nicoloff, H.; Kammerer, B.; Martinussen, J.; Bringel, F.
    Uracil salvage pathway in Lactobacillus plantarum: transcription and genetic studies (2006), J. Bacteriol., 188, 4777-4786.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.9

Cloned(Commentary)

Cloned (Comment) Organism
gene upp, upp gene is part of the lp_2376-glyA-upp operon, upp expression depends on the upp-pyrP gene cluster, pyrP encodes a high affinity uracil transporter, which is expressed and regulated independently of upp, overview Lactiplantibacillus plantarum

Protein Variants

Protein Variants Comment Organism
additional information seven independent upp mutants are constructed and found to excrete low amounts of pyrimidines to the growth medium, pyrimidine-dependent transcription regulation of the biosynthetic pyrimidine pyrR1-B-C-Aa1-Ab1-D-F-E operon is impaired in the upp mutants, overview, model of pyrP pyrimidine-dependent regulation by transcription attenuation Lactiplantibacillus plantarum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uracil + 5-phospho-alpha-D-ribose 1-diphosphate Lactiplantibacillus plantarum the enzyme is involved in the uracil salvage pathway, UPRT is a major cell supplier of UMP synthesized from uracil provided by preformed nucleic acid degradation, uracil salvage and pyrimidine biosynthetic pathways, overview UMP + diphosphate
-
 ?
uracil + 5-phospho-alpha-D-ribose 1-diphosphate Lactiplantibacillus plantarum BM604 the enzyme is involved in the uracil salvage pathway, UPRT is a major cell supplier of UMP synthesized from uracil provided by preformed nucleic acid degradation, uracil salvage and pyrimidine biosynthetic pathways, overview UMP + diphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Lactiplantibacillus plantarum Q9RE01 gene upp
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Lactiplantibacillus plantarum BM604 Q9RE01 gene upp
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Lactiplantibacillus plantarum UMP + diphosphate
-
 ?
uracil + 5-phospho-alpha-D-ribose 1-diphosphate the enzyme is involved in the uracil salvage pathway, UPRT is a major cell supplier of UMP synthesized from uracil provided by preformed nucleic acid degradation, uracil salvage and pyrimidine biosynthetic pathways, overview Lactiplantibacillus plantarum UMP + diphosphate
-
 ?
uracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Lactiplantibacillus plantarum BM604 UMP + diphosphate
-
 ?
uracil + 5-phospho-alpha-D-ribose 1-diphosphate the enzyme is involved in the uracil salvage pathway, UPRT is a major cell supplier of UMP synthesized from uracil provided by preformed nucleic acid degradation, uracil salvage and pyrimidine biosynthetic pathways, overview Lactiplantibacillus plantarum BM604 UMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
UPRT
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 Lactiplantibacillus plantarum
UPRTase
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 Lactiplantibacillus plantarum