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Literature summary for 2.5.1.10 extracted from

  • Thulasiram, H.V.; Poulter, C.D.
    Farnesyl diphosphate synthase: the art of compromise between substrate selectivity and stereoselectivity (2006), J. Am. Chem. Soc., 128, 15819-15823.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.10

Organism

Organism UniProt Comment Textmining
Artemisia tridentata
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Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylallyl diphosphate + isopentenyl diphosphate when (R)-[2-2H]IPP is a substrate for chain elongation, no deuterium is found in the chain elongation products. In contrast, the deuterium in (S)-[2-2H]IPP is incorporated into all of the products. Thus, the pro-R hydrogen at C2 of IPP is lost when the E- and Z-double bond isomers are formed Escherichia coli diphosphate + geranyl diphosphate
-
 ?
dimethylallyl diphosphate + isopentenyl diphosphate when (R)-[2-2H]IPP is a substrate for chain elongation, no deuterium is found in the chain elongation products. In contrast, the deuterium in (S)-[2-2H]IPP is incorporated into all of the products. Thus, the pro-R hydrogen at C2 of IPP is lost when the E- and Z-double bond isomers are formed Artemisia tridentata diphosphate + geranyl diphosphate
-
 ?
geranyl diphosphate + isopentenyl diphosphate small amounts of neryl diphosphate, (Z,E)-farnesyl diphosphate are formed along with the E-isomers. When (R)-[2-2H]IPP is a substrate for chain elongation, no deuterium is found in the chain elongation products. In contrast, the deuterium in (S)-[2-2H]IPP is incorporated into all of the products. Thus, the pro-R hydrogen at C2 of IPP is lost when the E- and Z-double bond isomers are formed Escherichia coli diphosphate + trans,trans-farnesyl diphosphate
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 ?
geranyl diphosphate + isopentenyl diphosphate small amounts of neryl diphosphate, (Z,E)-farnesyl diphosphate are formed along with the E-isomers. When (R)-[2-2H]IPP is a substrate for chain elongation, no deuterium is found in the chain elongation products. In contrast, the deuterium in (S)-[2-2H]IPP is incorporated into all of the products. Thus, the pro-R hydrogen at C2 of IPP is lost when the E- and Z-double bond isomers are formed Artemisia tridentata diphosphate + trans,trans-farnesyl diphosphate
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 ?

Synonyms

Synonyms Comment Organism
farnesyl diphosphate synthase
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 Escherichia coli
farnesyl diphosphate synthase
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 Artemisia tridentata