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Literature summary for 2.5.1.16 extracted from

  • Haider, N.; Eschbach, M.L.; Dias Sde, S.; Gilberger, T.W.; Walter, R.D.; Luersen, K.
    The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme (2005), Mol. Biochem. Parasitol., 142, 224-236.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli, without the first 29 amino acids of the N-terminal extension Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
1-Aminooxy-3-aminopropane poor inhibition Plasmodium falciparum
2-mercaptoethylamine poor inhibition Plasmodium falciparum
5'-methylthioadenosine feedback inhibition Plasmodium falciparum
5-amino-1-pentene 50% inhibition at 6.5 microM Plasmodium falciparum
Cyclohexylamine 50% inhibition at 19.7 microM Plasmodium falciparum
Dicyclohexylamine poor inhibition Plasmodium falciparum
additional information not inhibitory: S-adenosylmethioninamine concentrations up to 150 microM Plasmodium falciparum
trans-4-Methylcyclohexylamine IC50 1.4 microM Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0353
-
S-adenosylmethioninamine pH 7.0, 37°C Plasmodium falciparum
0.052
-
putrescine pH 7.0, 37°C Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Plasmodium falciparum 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
2 * 37000, SDS-PAGE Plasmodium falciparum
70000
-
gel filtration Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q9NFS5
-
-

Purification (Commentary)

Purification (Comment) Organism
metal affinity chromatography and gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
putrescine + S-adenosylmethioninamine
-
Plasmodium falciparum spermidine + 5'-methylthioadenosine
-
?
spermidine + S-adenosylmethioninamine in contrast to mammalian spermidine synthases, spermidine can replace to some extent putrescine as the aminopropyl acceptor Plasmodium falciparum spermine + 5'-methylthioadenosine
-
?

Subunits

Subunits Comment Organism
dimer 2 * 37000, SDS-PAGE Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00018
-
trans-4-Methylcyclohexylamine
-
Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0014
-
IC50 1.4 microM Plasmodium falciparum trans-4-Methylcyclohexylamine