Cloned (Comment) | Organism |
---|---|
gene spdS, overexpression in transgenic C57BL/6J mice | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of transgenic mice overexpressing the human SpdS, the mice are viable and fertile and tissue SpdS activity is increased up to 9fold. This increased SpdS activity does not result in a dramatic elevation of spermidine or spermine levels but leads to a 1.5 to 2fold reduction in tissue spermine:spermidine ratio in heart, muscle and liver tissues with the highest levels of SpdS activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosylmethioninamine + putrescine | Homo sapiens | - |
S-methyl-5'-thioadenosine + spermidine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosylmethioninamine + putrescine | - |
Homo sapiens | S-methyl-5'-thioadenosine + spermidine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SPDS | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | 7.2 | assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | spermidine synthhase is responsible for spermdine synthesis from putrescine, the polyamines putrescine, spermidine and spermine are cationic molecules that are found in all eukaryotic cells and are clearly essential to growth and development | Homo sapiens |