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Literature summary for 2.5.1.16 extracted from

  • Shi, C.; Welsh, P.A.; Sass-Kuhn, S.; Wang, X.; McCloskey, D.E.; Pegg, A.E.; Feith, D.J.
    Characterization of transgenic mice with overexpression of spermidine synthase (2012), Amino Acids, 42, 495-505.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene spdS, overexpression in transgenic C57BL/6J mice Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of transgenic mice overexpressing the human SpdS, the mice are viable and fertile and tissue SpdS activity is increased up to 9fold. This increased SpdS activity does not result in a dramatic elevation of spermidine or spermine levels but leads to a 1.5 to 2fold reduction in tissue spermine:spermidine ratio in heart, muscle and liver tissues with the highest levels of SpdS activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosylmethioninamine + putrescine Homo sapiens
-
S-methyl-5'-thioadenosine + spermidine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosylmethioninamine + putrescine
-
Homo sapiens S-methyl-5'-thioadenosine + spermidine
-
?

Synonyms

Synonyms Comment Organism
SPDS
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 7.2 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function spermidine synthhase is responsible for spermdine synthesis from putrescine, the polyamines putrescine, spermidine and spermine are cationic molecules that are found in all eukaryotic cells and are clearly essential to growth and development Homo sapiens