Literature summary for 2.5.1.19 extracted from

Baerson, S.R.; Rodriguez, D.J.; Tran, M.; Feng, Y.; Biest, N.A.; Dill, G.M.
Glyphosate-resistant goosegrass. Identification of a mutation in the target enzyme 5-enolpyruvylshikimate-3-phosphate synthase (2002), Plant Physiol., 129, 1265-1275.

Search for more literature for 2.5.1.19

Protein Variants

Protein Variants	Comment	Organism
P106S	glyphosate-insensitive	Eleusine indica
P381L	similiar glyphosate sensitivity like wild-type	Eleusine indica

Inhibitors

Inhibitors	Comment	Organism	Structure
N-phosphonomethylglycine	0.006 mM, 50% inhibition of glyphosate-sensitve strain, 0.03 mM, 50% inhibition of glyphosate-resistant strain	Eleusine indica
N-phosphonomethylglycine	-	Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0038	-	phosphoenolpyruvate	glyphosate-sensitive strain	Eleusine indica
0.007	-	phosphoenolpyruvate	glyphosate-resistant strain	Eleusine indica

Organism

Organism	UniProt	Comment	Textmining
Eleusine indica	-	goosegrass	-
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphoenolpyruvate + 3-phosphoshikimate	-	Salmonella enterica subsp. enterica serovar Typhimurium	phosphate + 5-enolpyruvylshikimate 3-phosphate	-	r
phosphoenolpyruvate + 3-phosphoshikimate	-	Eleusine indica	phosphate + 5-enolpyruvylshikimate 3-phosphate	-	r

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00076	-	N-phosphonomethylglycine	glyphosate-resistant strain	Eleusine indica
0.001	-	N-phosphonomethylglycine	P106S mutant enzyme	Eleusine indica
0.029	-	N-phosphonomethylglycine	P381L mutant enzyme	Eleusine indica
0.048	-	N-phosphonomethylglycine	glyphosate-sensitive strain	Eleusine indica

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Release 2023.1 (January 2023)