Application | Comment | Organism |
---|---|---|
drug development | more experimental data needed for effective structure-based drug design | Bacteria |
Crystallization (Comment) | Organism |
---|---|
molecular docking using known structures of EPSPS in complex with (R)-phosphonate analogue of the tetrahedral reaction intermediate | Bacteria |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glyphosate | 3-phosphoshikimate binding is prerequisite for glyphosate binding | Bacteria |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacteria | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate | ordered substrate binding with 3-phosphoshikimate being bound first | Bacteria |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
shikimate 3-phosphate + phosphoenolpyruvate | shikimate 3-phosphate binding site primarily at the N-terminal domain of the enzyme, phosphoenolpyruvate-binding mainly a the C-terminal domain | Bacteria | phosphate + 5-enolpyruvylshikimate 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-enolpyruvylshikimate 3-phosphate synthase | - |
Bacteria |
EPSP synthase | - |
Bacteria |
EPSPS | - |
Bacteria |