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Literature summary for 2.5.1.29 extracted from

  • Wang, G.; Dixon, R.A.
    Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis (2009), Proc. Natl. Acad. Sci. USA, 106, 9914-9919.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.29

Protein Variants

Protein Variants Comment Organism
additional information coexpression of both small and large subunits in Escherichia coli yields a heterodimeric enzyme exhibiting altered ratios of GPP and GGPP synthase activities and greatly enhanced catalytic efficiency. The heterodimeric geranyl(geranyl)diphosphate synthase G(G)PPS may be involved in myrcene biosynthesis in hop trichomes. The conserved CxxxC motif, where x can be any hydrophobic amino acid residue, plays a critical role of in physical interactions between the 2 subunits Humulus lupulus
additional information small subunit alone is inactive. Coexpression of both small and large subunits in Escherichia coli yields a heterodimeric enzyme exhibiting altered ratios of GPP and GGPP synthase activities and greatly enhanced catalytic efficiency. The heterodimeric geranyl(geranyl)diphosphate synthase G(G)PPS may be involved in myrcene biosynthesis in hop trichomes. The conserved CxxxC motif, where x can be any hydrophobic amino acid residue, plays a critical role of in physical interactions between the 2 subunits Humulus lupulus

Organism

Organism UniProt Comment Textmining
Humulus lupulus C4NAM7 small subunit
-
Humulus lupulus C4NAM8 large subunit
-

Source Tissue

Source Tissue Comment Organism Textmining
trichome
-
 Humulus lupulus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E,E)-farnesyl diphosphate + isopentenyl diphosphate heterodimer of small and large subunit Humulus lupulus diphosphate + geranylgeranyl diphosphate
-
 ?
dimethylallyl diphosphate + 3 isopentenyl diphosphate heterodimer of small and large subunit Humulus lupulus geranylgeranyl diphosphate + diphosphate
-
 ?
dimethylallyl diphosphate + isopentenyl diphosphate large subunit alone Humulus lupulus geranyl diphosphate + farnesyl diphosphate + geranylgeranyl diphosphate + diphosphate
-
 ?
geranyl diphosphate + 2 isopentenyl diphosphate heterodimer of small and large subunit Humulus lupulus geranylgeranyl diphosphate + diphosphate
-
 ?
additional information large subunit alone shows geranyl diphosphate synthase activity, producing geranyl diphosphate, farnesyl diphosphate, and geranylgeranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate in vitro Humulus lupulus ?
-
 ?