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Literature summary for 2.5.1.29 extracted from

  • Liu, C.; Sun, Z.; Shen, S.; Lin, L.; Li, T.; Tian, B.; Hua, Y.
    Identification and characterization of the geranylgeranyl diphosphate synthase in Deinococcus radiodurans (2014), Lett. Appl. Microbiol., 58, 219-224.
    View publication on PubMed
Search for more literature for 2.5.1.29

Cloned(Commentary)

Cloned (Comment) Organism
gene DR1395, DNA and amino acid sequence determination and analysis, sequence comparison with gene DR0932, recombinant expression in Escherichia coli strain BL21 Deinococcus radiodurans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate Deinococcus radiodurans
-
 diphosphate + geranylgeranyl diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
-
 diphosphate + geranylgeranyl diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Deinococcus radiodurans Q9RUJ1 gene DR1395
-
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 Q9RUJ1 gene DR1395
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
-
 Deinococcus radiodurans diphosphate + geranylgeranyl diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
-
 Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 diphosphate + geranylgeranyl diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
DR1395
-
 Deinococcus radiodurans
GGPP synthase
-
 Deinococcus radiodurans
GGPPS
-
 Deinococcus radiodurans

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the entrance step in the deinoxanthin biosynthetic pathway Deinococcus radiodurans
physiological function the amino acid composition of and around the first aspartate-rich motif of the enzyme is vital for GGPP synthase function. Enzyme DR1395 functions as GGPPS to provide GGPP for the biosynthesis of phytoene and then lycopene Deinococcus radiodurans