Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.29 extracted from

  • Ruiz-Sola, M.A.; Coman, D.; Beck, G.; Barja, M.V.; Colinas, M.; Graf, A.; Welsch, R.; Ruetimann, P.; Buehlmann, P.; Bigler, L.; Gruissem, W.; Rodriguez-Concepcion, M.; Vranova, E.
    Arabidopsis geranylgeranyl diphosphate synthase 11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids (2016), New Phytol., 209, 252-264.
    View publication on PubMed
Search for more literature for 2.5.1.29

Cloned(Commentary)

Cloned (Comment) Organism
gene GGPPS11, constructs containing the GGPPS11 promoter and/or coding region are constructed and used for Agrobacterium-mediated transformation of Arabidopsis thaliana wild-type and GGPPS11-defective mutant plants, mutant genotyping, overview. Quantitative reverse transcription PCR analysis of wild-type and mutant GGPPS11 enzyme expression Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information construction of several GGPPS11 homozygous transgenic lines containing each a single T-DNA insertion that inactivates gene GGPPS11, mutant genotyping, overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana the GGPPS11 protein physically interacts with enzymes that use GGPP for the production of carotenoids, chlorophylls, tocopherols, phylloquinone, and plastoquinone ?
-
 ?
additional information Arabidopsis thaliana Col-0 the GGPPS11 protein physically interacts with enzymes that use GGPP for the production of carotenoids, chlorophylls, tocopherols, phylloquinone, and plastoquinone ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana P34802 gene GGPPS11
-
Arabidopsis thaliana Col-0 P34802 gene GGPPS11
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the GGPPS11 protein physically interacts with enzymes that use GGPP for the production of carotenoids, chlorophylls, tocopherols, phylloquinone, and plastoquinone Arabidopsis thaliana ?
-
 ?
additional information the GGPPS11 protein physically interacts with enzymes that use GGPP for the production of carotenoids, chlorophylls, tocopherols, phylloquinone, and plastoquinone Arabidopsis thaliana Col-0 ?
-
 ?

Synonyms

Synonyms Comment Organism
geranylgeranyl diphosphate synthase 11
-
 Arabidopsis thaliana
GGPP synthase
-
 Arabidopsis thaliana
GGPPS
-
 Arabidopsis thaliana
GGPPS1 UniProt Arabidopsis thaliana
GGPPS11
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction reduced GGPPS11 levels in the ggpps11-5 allele result in pale plants with smaller mesophyll chloroplasts. Levels of chlorophylls (a and b), carotenoids (beta-carotene, violaxanthin, neoxanthin, and lutein) and prenylquinones such as tocopherols (alpha-tocopherol and gamma-tocopherol), plastoquinones (plastochromanol-8 and plastoquinone-9) and phylloquinone are significantly reduced in ggpps11-5 seedlings, whereas complemented lines show a metabolite profile similar to that of wild-type controls, phenotype, overview Arabidopsis thaliana
metabolism geranylgeranyl diphosphate is synthesized in different compartments by GGPP synthase (GGPPS) enzymes (the numbers refer to the Arabidopsis thaliana isoforms). Some of the enzymes channel geranylgeranyl diphosphate to specific isoprenoid pathways, isoprenoid biosynthesis in plant cell compartments, overview Arabidopsis thaliana
physiological function gene GGPPS11, encoding the only plastid isozyme essential for plant development, functions as a hub gene among GGPPS paralogues and is required for the production of all major groups of plastid isoprenoids. Both gene co-expression and protein-protein interaction likely contribute to the channeling of geranylgeranyl diphosphate by GGPPS11. Metabolite analysis confirms the essential role of GGPPS11 in plastid isoprenoid metabolism. Isozyme GGPPS11 interacts with plastid enzymes that use geranylgeranyl diphosphate as substrate Arabidopsis thaliana