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Literature summary for 2.5.1.32 extracted from

  • Kachanovsky, D.E.; Filler, S.; Isaacson, T.; Hirschberg, J.
    Epistasis in tomato color mutations involves regulation of phytoene synthase 1 expression by cis-carotenoids (2012), Proc. Natl. Acad. Sci. USA, 109, 19021-19026.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.32

Cloned(Commentary)

Cloned (Comment) Organism
cloning and genetic analysis of fruit-specific phytoene synthase, PSY1, and mutant lines tangerine and yellow-flesh with mutant alleles t3183 and r2997, respectively Solanum lycopersicum

Protein Variants

Protein Variants Comment Organism
G520R naturally occuring mutation in allele t3406 Solanum lycopersicum
G546E naturally occuring mutation in allele t9776 Solanum lycopersicum
L241K naturally occuring mutation in allele t4838 Solanum lycopersicum
additional information a frameshift mutation due to a single-nucleotide insertion in codon 226 of CRTISO, which leads to an early stop codon, was found in t3002. The other alleles in the M82 variety carry missense mutations: L241K in t4838, G520R in t3406, and G546E in t9776. Expression analysis of wild-type and mutant enzymes in vivo and comparisons, overview Solanum lycopersicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate Solanum lycopersicum
-
 15-cis-phytoene + 2 diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Solanum lycopersicum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fruit
-
 Solanum lycopersicum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate
-
 Solanum lycopersicum 15-cis-phytoene + 2 diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
fruit-specific phytoene synthase
-
 Solanum lycopersicum
phytoene synthase 1
-
 Solanum lycopersicum
PSY1
-
 Solanum lycopersicum

General Information

General Information Comment Organism
malfunction the recessive mutation yellow-flesh (locus r) in tomato eliminates fruit carotenoids by disrupting the activity of the fruit-specific phytoene synthase, PSY1, allele r2997 of yellow-flesh eliminates transcription of PSY1 in fruits. Fruits of the recessive mutation tangerine (t) appear orange due to accumulation of 7,9,7',9'-tetra-cis-lycopene (prolycopene) as a result of a mutation in the carotenoid cis-trans isomerase, tangerine is epistatic to yellow-flesh, interaction between tangerine and yellow-flesh at the molecular level, overview Solanum lycopersicum
metabolism PSY1 catalyzes the first committed step in the carotenoid biosynthesis pathway, the formation of phytoene from two molecules of geranylgeranyl diphosphate Solanum lycopersicum
physiological function molecular mechanism underlying the epistasis of mutations tangerine over yellow-flesh and suggest the involvement of cis-carotenoid metabolites in a feedback regulation of PSY1 gene expression Solanum lycopersicum