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Literature summary for 2.5.1.46 extracted from

  • Ober, D.; Hartmann, T.
    Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved form deoxyhypusine synthase (1999), Proc. Natl. Acad. Sci. USA, 96, 14777-14782.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.46

Cloned(Commentary)

Cloned (Comment) Organism
-
 Senecio vernalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[eIF5A-precursor]-lysine + spermidine Senecio vernalis
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Organism

Organism UniProt Comment Textmining
Senecio vernalis Q9SC14
-
-

Source Tissue

Source Tissue Comment Organism Textmining
shoot tip
-
 Senecio vernalis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0101
-
 with acceptor eIF5A-prcursor Senecio vernalis
0.0442
-
 with acceptor putrescine Senecio vernalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
spermidine + putrescine
-
 Senecio vernalis homospermidine + ?
-
 ?
[eIF5A-precursor]-lysine + spermidine
-
 Senecio vernalis [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
[eIF5A-precursor]-lysine + spermidine
-
 Senecio vernalis [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Senecio vernalis
NADH
-
 Senecio vernalis