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Literature summary for 2.5.1.59 extracted from

  • Wilson, A.L.; Erdman, R.A.; Castellano, F.; Maltese, W.A.
    Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases (1998), Biochem. J., 333, 497-504.
No PubMed abstract available
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Cloned(Commentary)

Cloned (Comment) Organism
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 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
GGTI-297
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 Rattus norvegicus
GGTI-298
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 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine the Rab protein Rab8-GTPase, which ends with a Cys-Val-Leu-Leu motif is able to serve as a substrate for either geranylgeranyl transferase I and II, but modified predominantly by geranylgeranyl transferase II, Y78D mutation selective prevents prenylation of Rab8 by geranylgeranyl transferase II, but not geranylgeranyltransferaseI Rattus norvegicus S-geranylgeranyl-protein + diphosphate
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