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Literature summary for 2.5.1.59 extracted from

  • Hartman, H.L.; Hicks, K.A.; Fierke, C.A.
    Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity (2005), Biochemistry, 44, 15314-15324.
    View publication on PubMed
Search for more literature for 2.5.1.59

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain BL21(DE3) GGPT/pET23a Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + Ki-Ras4B
-
 Escherichia coli diphosphate + S-geranylgeranyl-Ki-Ras4B
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Ala
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Ala
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Arg
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Arg
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Asn
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Asn
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Asp
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Asp
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Cys
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Cys
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Gln
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Gln
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Ile
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Ile
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Leu
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Leu
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Met
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Met
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Phe
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Phe
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Ser
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Ser
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Thr
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Thr
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Tyr
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Tyr
-
 ?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Val
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Val
-
 ?

Synonyms

Synonyms Comment Organism
GGTaseI
-
 Escherichia coli
protein geranylgeranyltransferase type I
-
 Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.001
-
 Thr-Lys-Cys-Val-Ile-Ser in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.001
-
 Thr-Lys-Cys-Val-Ile-Ala in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.001
-
 Thr-Lys-Cys-Val-Ile-Asp in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.001
-
 Thr-Lys-Cys-Val-Ile-Asn in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.001
-
 Thr-Lys-Cys-Val-Ile-Gln in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.001
-
 Thr-Lys-Cys-Val-Ile-Arg in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.001
-
 Thr-Lys-Cys-Val-Ile-Thr in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.0063
-
 Thr-Lys-Cys-Val-Ile-Cys in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.022
-
 Thr-Lys-Cys-Val-Ile-Tyr in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.048
-
 Thr-Lys-Cys-Val-Ile-Ile in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.06
-
 Thr-Lys-Cys-Val-Ile-Phe in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.082
-
 Thr-Lys-Cys-Val-Ile-Met in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.088
-
 Thr-Lys-Cys-Val-Ile-Leu in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
0.107
-
 Thr-Lys-Cys-Val-Ile-Val in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli