Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GGTi-2147 | a potent and selective inhibitor of GGT; potent and selective inhibitor of GGT | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | the spatiotemporal expression pattern of GGT is correlated with the synaptogenesis in vivo | Rattus norvegicus | - |
- |
synapse | GGTalpha and GGTbeta are enriched in synaptosome and postsynaptic density fractions from P14 hippocampus | Rattus norvegicus | 45202 | - |
synaptosome | GGTalpha and GGTbeta are enriched in synaptosome and postsynaptic density fractions from P14 hippocampus | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + Cdc42-cysteine | Rattus norvegicus | - |
S-geranylgeranyl-Cdc42 + diphosphate | - |
? | |
geranylgeranyl diphosphate + Cdc42-cysteine | Rattus norvegicus Sprague-Dawley | - |
S-geranylgeranyl-Cdc42 + diphosphate | - |
? | |
geranylgeranyl diphosphate + protein-cysteine | Rattus norvegicus | - |
S-geranylgeranyl-protein + diphosphate | - |
? | |
geranylgeranyl diphosphate + protein-cysteine | Rattus norvegicus Sprague-Dawley | - |
S-geranylgeranyl-protein + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rac-cysteine | Rattus norvegicus | - |
S-geranylgeranyl-Rac + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rac-cysteine | Rattus norvegicus Sprague-Dawley | - |
S-geranylgeranyl-Rac + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rap1A-cysteine | Rattus norvegicus | - |
S-geranylgeranyl-Rap1A + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rap1A-cysteine | Rattus norvegicus Sprague-Dawley | - |
S-geranylgeranyl-Rap1A + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rho GTPase-cysteine | Rattus norvegicus | - |
S-geranylgeranyl-Rho GTPase + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rho GTPase-cysteine | Rattus norvegicus Sprague-Dawley | - |
S-geranylgeranyl-Rho GTPase + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P53610 | subunit beta | - |
Rattus norvegicus | Q04631 | subunit alpha | - |
Rattus norvegicus Sprague-Dawley | P53610 | subunit beta | - |
Rattus norvegicus Sprague-Dawley | Q04631 | subunit alpha | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
central nervous system | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
neuron | hippocampal and cortical | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + Cdc42-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-Cdc42 + diphosphate | - |
? | |
geranylgeranyl diphosphate + Cdc42-cysteine | - |
Rattus norvegicus Sprague-Dawley | S-geranylgeranyl-Cdc42 + diphosphate | - |
? | |
geranylgeranyl diphosphate + protein-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-protein + diphosphate | - |
? | |
geranylgeranyl diphosphate + protein-cysteine | - |
Rattus norvegicus Sprague-Dawley | S-geranylgeranyl-protein + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rac-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-Rac + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rac-cysteine | - |
Rattus norvegicus Sprague-Dawley | S-geranylgeranyl-Rac + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rap1A-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-Rap1A + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rap1A-cysteine | - |
Rattus norvegicus Sprague-Dawley | S-geranylgeranyl-Rap1A + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rho GTPase-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-Rho GTPase + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rho GTPase-cysteine | - |
Rattus norvegicus Sprague-Dawley | S-geranylgeranyl-Rho GTPase + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | the enzyme includes two subunits: an alpha subunit (GGTalpha), the catalytic subunit, that is shared with farnesyltransferase, EC 2.5.1.58, and a distinct beta subunit (GGTbeta), which is responsible for substrate binding | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
geranylgeranyltransferase I | - |
Rattus norvegicus |
GGT | - |
Rattus norvegicus |
GGTalpha | - |
Rattus norvegicus |
GGTbeta | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | downregulation or inhibition of GGT decreases synaptogenesis | Rattus norvegicus |
malfunction | overexpression of GGTbeta promotes the linear density of post-synaptic density protein 95 (PSD 95) and synapsin 1, two major molecular markers of synaptogenesis, while downregulation or inhibition of GGT decreases synaptogenesis | Rattus norvegicus |
additional information | the enzyme includes two subunits: an alpha subunit (GGTalpha), the catalytic subunit, that is shared with farnesyltransferase, EC 2.5.1.58, and a distinct beta subunit (GGTbeta), which is responsible for substrate binding | Rattus norvegicus |
physiological function | the enzyme mediates lipid modification of Rho small GTPases, such as Rho, Rac, and Cdc42, which are important for neuronal synaptogenesis. It promotes the basal and neuronal activity and brain-derived neurotrophic factor (BDNF)-induced dendritic morphogenesis of cultured hippocampal neurons and cerebellar slices. Function and mechanism of geranylgeranyltransferase I in neuronal synaptogenesis, enzyme regulation by factors that promote synaptogenesis, overview. The activities of GGT and Rac are regulated by BDNF | Rattus norvegicus |