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Literature summary for 2.5.1.59 extracted from

  • Li, Z.; Sun, C.; Zhang, T.; Mo, J.; Shi, Q.; Zhang, X.; Yuan, M.; Chen, L.; Mao, X.; Yu, R.; Zhou, X.
    Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis (2013), J. Neurochem., 125, 698-712.
    View publication on PubMed
Search for more literature for 2.5.1.59

Inhibitors

Inhibitors Comment Organism Structure
GGTi-2147 a potent and selective inhibitor of GGT; potent and selective inhibitor of GGT Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the spatiotemporal expression pattern of GGT is correlated with the synaptogenesis in vivo Rattus norvegicus
-
-
synapse GGTalpha and GGTbeta are enriched in synaptosome and postsynaptic density fractions from P14 hippocampus Rattus norvegicus 45202
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synaptosome GGTalpha and GGTbeta are enriched in synaptosome and postsynaptic density fractions from P14 hippocampus Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate + Cdc42-cysteine Rattus norvegicus
-
 S-geranylgeranyl-Cdc42 + diphosphate
-
 ?
geranylgeranyl diphosphate + Cdc42-cysteine Rattus norvegicus Sprague-Dawley
-
 S-geranylgeranyl-Cdc42 + diphosphate
-
 ?
geranylgeranyl diphosphate + protein-cysteine Rattus norvegicus
-
 S-geranylgeranyl-protein + diphosphate
-
 ?
geranylgeranyl diphosphate + protein-cysteine Rattus norvegicus Sprague-Dawley
-
 S-geranylgeranyl-protein + diphosphate
-
 ?
geranylgeranyl diphosphate + Rac-cysteine Rattus norvegicus
-
 S-geranylgeranyl-Rac + diphosphate
-
 ?
geranylgeranyl diphosphate + Rac-cysteine Rattus norvegicus Sprague-Dawley
-
 S-geranylgeranyl-Rac + diphosphate
-
 ?
geranylgeranyl diphosphate + Rap1A-cysteine Rattus norvegicus
-
 S-geranylgeranyl-Rap1A + diphosphate
-
 ?
geranylgeranyl diphosphate + Rap1A-cysteine Rattus norvegicus Sprague-Dawley
-
 S-geranylgeranyl-Rap1A + diphosphate
-
 ?
geranylgeranyl diphosphate + Rho GTPase-cysteine Rattus norvegicus
-
 S-geranylgeranyl-Rho GTPase + diphosphate
-
 ?
geranylgeranyl diphosphate + Rho GTPase-cysteine Rattus norvegicus Sprague-Dawley
-
 S-geranylgeranyl-Rho GTPase + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P53610 subunit beta
-
Rattus norvegicus Q04631 subunit alpha
-
Rattus norvegicus Sprague-Dawley P53610 subunit beta
-
Rattus norvegicus Sprague-Dawley Q04631 subunit alpha
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
central nervous system
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-
neuron hippocampal and cortical Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + Cdc42-cysteine
-
 Rattus norvegicus S-geranylgeranyl-Cdc42 + diphosphate
-
 ?
geranylgeranyl diphosphate + Cdc42-cysteine
-
 Rattus norvegicus Sprague-Dawley S-geranylgeranyl-Cdc42 + diphosphate
-
 ?
geranylgeranyl diphosphate + protein-cysteine
-
 Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
 ?
geranylgeranyl diphosphate + protein-cysteine
-
 Rattus norvegicus Sprague-Dawley S-geranylgeranyl-protein + diphosphate
-
 ?
geranylgeranyl diphosphate + Rac-cysteine
-
 Rattus norvegicus S-geranylgeranyl-Rac + diphosphate
-
 ?
geranylgeranyl diphosphate + Rac-cysteine
-
 Rattus norvegicus Sprague-Dawley S-geranylgeranyl-Rac + diphosphate
-
 ?
geranylgeranyl diphosphate + Rap1A-cysteine
-
 Rattus norvegicus S-geranylgeranyl-Rap1A + diphosphate
-
 ?
geranylgeranyl diphosphate + Rap1A-cysteine
-
 Rattus norvegicus Sprague-Dawley S-geranylgeranyl-Rap1A + diphosphate
-
 ?
geranylgeranyl diphosphate + Rho GTPase-cysteine
-
 Rattus norvegicus S-geranylgeranyl-Rho GTPase + diphosphate
-
 ?
geranylgeranyl diphosphate + Rho GTPase-cysteine
-
 Rattus norvegicus Sprague-Dawley S-geranylgeranyl-Rho GTPase + diphosphate
-
 ?

Subunits

Subunits Comment Organism
dimer the enzyme includes two subunits: an alpha subunit (GGTalpha), the catalytic subunit, that is shared with farnesyltransferase, EC 2.5.1.58, and a distinct beta subunit (GGTbeta), which is responsible for substrate binding Rattus norvegicus

Synonyms

Synonyms Comment Organism
geranylgeranyltransferase I
-
 Rattus norvegicus
GGT
-
 Rattus norvegicus
GGTalpha
-
 Rattus norvegicus
GGTbeta
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus

General Information

General Information Comment Organism
malfunction downregulation or inhibition of GGT decreases synaptogenesis Rattus norvegicus
malfunction overexpression of GGTbeta promotes the linear density of post-synaptic density protein 95 (PSD 95) and synapsin 1, two major molecular markers of synaptogenesis, while downregulation or inhibition of GGT decreases synaptogenesis Rattus norvegicus
additional information the enzyme includes two subunits: an alpha subunit (GGTalpha), the catalytic subunit, that is shared with farnesyltransferase, EC 2.5.1.58, and a distinct beta subunit (GGTbeta), which is responsible for substrate binding Rattus norvegicus
physiological function the enzyme mediates lipid modification of Rho small GTPases, such as Rho, Rac, and Cdc42, which are important for neuronal synaptogenesis. It promotes the basal and neuronal activity and brain-derived neurotrophic factor (BDNF)-induced dendritic morphogenesis of cultured hippocampal neurons and cerebellar slices. Function and mechanism of geranylgeranyltransferase I in neuronal synaptogenesis, enzyme regulation by factors that promote synaptogenesis, overview. The activities of GGT and Rac are regulated by BDNF Rattus norvegicus