Application | Comment | Organism |
---|---|---|
drug development | the enzyme form has a less extensive subunit interface than some previously determined structures, and contains some key structural differences from the human enzyme in an allosteric site, presenting an opportunity for the design of selective inhibitors against the S-adenosylmethionine synthetase from this organism | Cryptosporidium parvum |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Cryptosporidium parvum |
Crystallization (Comment) | Organism |
---|---|
hanging-drop vapor diffusion method at 20°C | Cryptosporidium parvum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | Cryptosporidium parvum | - |
phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
ATP + L-methionine + H2O | Cryptosporidium parvum Iowa II | - |
phosphate + diphosphate + S-adenosyl-L-methionine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptosporidium parvum | Q5CYE4 | - |
- |
Cryptosporidium parvum Iowa II | Q5CYE4 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Cryptosporidium parvum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | - |
Cryptosporidium parvum | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
ATP + L-methionine + H2O | - |
Cryptosporidium parvum Iowa II | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AdoMet synthetase | - |
Cryptosporidium parvum |
MetK | - |
Cryptosporidium parvum |
S-adenosylmethionine synthetase | - |
Cryptosporidium parvum |
General Information | Comment | Organism |
---|---|---|
metabolism | S-adenosyl-L-methionine (AdoMet) is the primary methyl donor in most biological methylation reactions, is produced from ATP and methionine in a multistep reaction catalyzed by AdoMet synthetase. The diversity of group transfer reactions that involve AdoMet places this compound at a key crossroads in amino-acid, nucleic acid and lipid metabolism | Cryptosporidium parvum |