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Literature summary for 2.5.1.60 extracted from

  • Farnsworth, C.C.; Seabra, M.C.; Ericsson, L.H.; Gelb, M.H.; Glomset, J.A.
    Rab geranylgeranyl transferase catalyses the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A (1994), Proc. Natl. Acad. Sci. USA, 91, 11963-11967.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant enzyme produced in insect cells Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate mechanism, recombinant enzyme/REP-1 complex catalyzes the geranylgeranylation of both adjacent cysteines in Rab1A, Rab3A and Rab5A Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine
-
Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
?
geranylgeranyl diphosphate + Rab1A substrate motif: -XXCC Rattus norvegicus ?
-
?
geranylgeranyl diphosphate + Rab3A substrate motif: -XCXC Rattus norvegicus ?
-
?
geranylgeranyl diphosphate + Rab5A substrate motif: -CCXX Rattus norvegicus ?
-
?