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Literature summary for 2.5.1.60 extracted from

  • Thomä, N.H.; Iakovenko, A.; Owen, D.; Scheidig, A.S.; Waldmann, H.; Goody, R.S.; Alexandrov, K.
    Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II (2000), Biochemistry, 39, 12043-12052.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in SF21 cells Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ not requirement Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate mechanism Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine
-
Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
?
additional information farnesyl diphosphate and geranylgeranyl diphosphate bind to enzyme with very similar rate constant, but the binding mechanism of farnesyl diphosphate differs from that of geranylgeranyl diphosphate, shortening of the isoprenoid chain leads to a drastic decreases in affinity Rattus norvegicus ?
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?