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Literature summary for 2.5.1.60 extracted from

  • Loraine, A.E.; Yalovsky, S.; Fabry, S.; Gruissen, W.
    Tomato Rab1A homologs as molecular tools for studying Rab geranylgeranyl transferase in plant cells (1996), Plant Physiol., 110, 1337-1347.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Nonidet P-40
-
Saccharomyces cerevisiae
Nonidet P-40 the plant enzyme activity is enhanced by detergent Nicotiana tabacum
Nonidet P-40 the plant enzyme activity is enhanced by detergent Solanum lycopersicum

Inhibitors

Inhibitors Comment Organism Structure
additional information plant enzyme is inhibited by mutant Rab lacking a prenylation consence sequence Nicotiana tabacum
additional information plant enzyme is inhibited by mutant Rab lacking a prenylation consence sequence Solanum lycopersicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine Saccharomyces cerevisiae
-
S-geranylgeranyl-protein + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Nicotiana tabacum
-
-
-
Saccharomyces cerevisiae
-
-
-
Solanum lycopersicum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine
-
Saccharomyces cerevisiae S-geranylgeranyl-protein + diphosphate
-
?
geranylgeranyl diphosphate + protein-cysteine enzyme attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family, Ypt/Sec4 in lower eukaryotes, that terminate in XXCC, XCXC and CCXX motifs, reaction only if Rab is bound to a carrier protein termed Rab escort protein, REP Saccharomyces cerevisiae S-geranylgeranyl-protein + diphosphate
-
?
geranylgeranyl diphosphate + protein-cysteine substrate are three tomato cDNAs endcoding Rab-like proteins: LeRab1A, B and C with mutant and wild-type prenylation motif, LeRab1B is the best substrate for the plant enzyme, but LeRab1A is the best substrate for yeast enzyme Saccharomyces cerevisiae S-geranylgeranyl-protein + diphosphate
-
?
geranylgeranyl diphosphate + protein-cysteine substrate are three tomato cDNAs endcoding Rab-like proteins: LeRab1A, B and C with mutant and wild-type prenylation motif, LeRab1B is the best substrate for the plant enzyme, but LeRab1A is the best substrate for yeast enzyme Nicotiana tabacum S-geranylgeranyl-protein + diphosphate
-
?
geranylgeranyl diphosphate + protein-cysteine substrate are three tomato cDNAs endcoding Rab-like proteins: LeRab1A, B and C with mutant and wild-type prenylation motif, LeRab1B is the best substrate for the plant enzyme, but LeRab1A is the best substrate for yeast enzyme Solanum lycopersicum S-geranylgeranyl-protein + diphosphate
-
?