Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is absolutely dependent on the Rab escort protein, REP, cloning and expression of His-tagged REP in Escherichia coli, and purification, overview, recombinant Arabidopsis thaliana REP-6His stimulates Rab geranylgeranylation activity in plant but not yeast cell extracts, overview | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | recombinant Arabidopsis thaliana REP interacts with yeast 6His-Ypt1, tobacco 6His-RabA1a, and Arabidopsis RabA2a in vitro preferring the GDP-bound form of the latter | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Arabidopsis thaliana | 5737 | - |
additional information | subcellular localization study, overview | Arabidopsis thaliana | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + Rab protein | Arabidopsis thaliana | intracellular vesicular trafficking is regulated by Rab proteins, small GTPases that require posttranslational geranylgeranylation for biological activity, which is catalyzed by the enzyme, a Rab geranylgeranyl transferase in complex with the Rab escort protein, REP, overview | S-geranylgeranyl-Rab protein + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seedling | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + Rab protein | intracellular vesicular trafficking is regulated by Rab proteins, small GTPases that require posttranslational geranylgeranylation for biological activity, which is catalyzed by the enzyme, a Rab geranylgeranyl transferase in complex with the Rab escort protein, REP, overview | Arabidopsis thaliana | S-geranylgeranyl-Rab protein + diphosphate | - |
? | |
geranylgeranyl diphosphate + Rab protein | with recombinantly expressed His6-tagged Saccharomyces cerevisiae Rab GTPase Ypt1 and Nicotiana tabacum NtaRabA1a in vitro substrates, overview | Arabidopsis thaliana | S-geranylgeranyl-Rab protein + diphosphate | - |
? | |
additional information | the enzyme is complexed with the Rab escort protein, REP, recombinant Arabidopsis thaliana REP interacts with yeast 6His-Ypt1, tobacco 6His-RabA1a, and Arabidopsis RabA2a in vitro preferring the GDP-bound form of the latter, overview, enzyme activity with different REPs, wild-type and mutant REPs, and involved REP residues, overview | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Rab geranylgeranyl transferase | - |
Arabidopsis thaliana |
RabGGTase | - |
Arabidopsis thaliana |