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Literature summary for 2.5.1.61 extracted from
- Uroporphyrinogen I synthetase from human erythrocytes: Separation, purification, and properties of isoenzymes (1979), Proc. Natl. Acad. Sci. USA, 76, 6172-6176.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
gel filtration, fraction A and B | Homo sapiens |
| 38000 | - |
1 * 38000, SDS-PAGE, B1 | Homo sapiens |
| 39500 | - |
1 * 39500, SDS-PAGE, B2 and B3 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| porphobilinogen | Homo sapiens | - |
? | - |
? |  |
| porphobilinogen | Bos taurus | - |
? | - |
? | |
| porphobilinogen | Cereibacter sphaeroides | - |
? | - |
? | |
| porphobilinogen | Spinacia oleracea | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cereibacter sphaeroides | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Spinacia oleracea | - |
spinach | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 3 isoenzymes | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| callus | tissue | Bos taurus | - |
| erythrocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
| additional information | - |
- |
Cereibacter sphaeroides |
Storage Stability
| Storage Stability | Organism |
|---|---|
| purified enzyme loses its activity when it is frozen | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Homo sapiens | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Bos taurus | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Cereibacter sphaeroides | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Spinacia oleracea | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Homo sapiens | hydroxylmethylbilane + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Bos taurus | hydroxylmethylbilane + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Cereibacter sphaeroides | hydroxylmethylbilane + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Spinacia oleracea | hydroxylmethylbilane + 4 NH3 | - |
? | |
| porphobilinogen | - |
Homo sapiens | ? | - |
? | |
| porphobilinogen | - |
Bos taurus | ? | - |
? | |
| porphobilinogen | - |
Cereibacter sphaeroides | ? | - |
? | |
| porphobilinogen | - |
Spinacia oleracea | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Cereibacter sphaeroides |
| monomer | 1 * 38000, SDS-PAGE, B1 | Homo sapiens |
| monomer | 1 * 39500, SDS-PAGE, B2 and B3 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| porphobilinogen deaminase | - |
Homo sapiens |
| porphobilinogen deaminase | - |
Cereibacter sphaeroides |
| UPGI-S | - |
Homo sapiens |
| uroporphyrinogen I synthase | - |
Homo sapiens |
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