Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.61 extracted from

  • Chakrabarty, B.; Das, D.; Bung, N.; Roy, A.; Bulusu, G.
    Network analysis of hydroxymethylbilane synthase dynamics (2020), J. Mol. Graph. Model., 99, 107641 .
    View publication on PubMed

Application

Application Comment Organism
medicine network analysis of residues involved in acute intermittent porphyria. Residues R150, R26 and Q217 are critical for the catalytic activity as they facilitate the interaction between the structural clusters and the active site Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
network analysis identifies 13 structural clusters persistent across five molecular dynamics trajectories corresponding to the five steps of pyrrole polymerization, which are responsible for maintaining the tertiary structure and domain arrangements of the enzyme. Amino acid residues R26 and F77 regulate the active site loop movement across the stages Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08397
-
-

Cofactor

Cofactor Comment Organism Structure
dipyrromethane the residues of the domains 1 and 2 interact with the cofactor in a coordinated way to facilitate the catalytic activity Homo sapiens