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Literature summary for 2.5.1.66 extracted from

  • Tahlan, K.; Park, H.U.; Wong, A.; Beatty, P.H.; Jensen, S.E.
    Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus (2004), Antimicrob. Agents Chemother., 48, 930-939.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information ceaS1 mutants with reduced clavulanic acid production compared with wild-type strain, ceaS1/ceaS2 double mutants and ceaS2 frameshift mutants with completely blocked clavulanic acid biosynthesis Streptomyces clavuligerus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59078
-
x * 59078, CeaS1, sequence calculation Streptomyces clavuligerus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glyceraldehyde 3-phosphate + L-arginine Streptomyces clavuligerus catalyzes the first reaction of the clavulanic acid biosynthesis pathway N2-(2-carboxyethyl)-L-arginine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces clavuligerus Q6TA05 wild-type strain NRRL3585, two paralogous genes ceaS1 and ceaS2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + L-arginine
-
Streptomyces clavuligerus N2-(2-carboxyethyl)-L-arginine + phosphate
-
?
D-glyceraldehyde 3-phosphate + L-arginine catalyzes the first reaction of the clavulanic acid biosynthesis pathway Streptomyces clavuligerus N2-(2-carboxyethyl)-L-arginine + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 59078, CeaS1, sequence calculation Streptomyces clavuligerus

Synonyms

Synonyms Comment Organism
carboxyethylarginine synthase
-
Streptomyces clavuligerus
CEAS
-
Streptomyces clavuligerus

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate thiamine diphosphate-dependent Streptomyces clavuligerus