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Literature summary for 2.5.1.7 extracted from

  • Mihalovits, L.M.; Ferenczy, G.G.; Keseru, G.M.
    Catalytic mechanism and covalent inhibition of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) Implications to the design of novel antibacterials (2019), J. Chem. Inf. Model., 59, 5161-5173 .
    View publication on PubMed
Search for more literature for 2.5.1.7

Inhibitors

Inhibitors Comment Organism Structure
additional information insight into the catalytic mechanism and covalent inhibition by QM/MM MD simulations Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine Escherichia coli the enzyme catalyzes the first step in the biosynthesis of the bacterial cell wall phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A749
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine
-
 Escherichia coli phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
-
 ?
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine the enzyme catalyzes the first step in the biosynthesis of the bacterial cell wall Escherichia coli phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
-
 ?

Synonyms

Synonyms Comment Organism
MurA
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 Escherichia coli

General Information

General Information Comment Organism
drug target catalyzes the first step in the biosynthesis of the bacterial cell wall. This pathway is essential for the growth of bacteria but missing in mammals, that nominates MurA as an attractive antibacterial target Escherichia coli
metabolism the enzyme catalyzes the first step in the biosynthesis of the bacterial cell wall Escherichia coli