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Literature summary for 2.6.1.1 extracted from

  • Jia, Y.; Lu, L.; Yuan, C.; Feng, S.; Zhu, M.
    Aspartate aminotransferase is potently inhibited by copper complexes Exploring copper complex-binding proteome (2017), J. Inorg. Biochem., 170, 46-54 .
    View publication on PubMed
Search for more literature for 2.6.1.1

Inhibitors

Inhibitors Comment Organism Structure
(2-chloro-6-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)(2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)copper
-
 Rattus norvegicus
(2-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)(2-hydroxyethyl)(2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)cuprate(1-)
-
 Rattus norvegicus
aqua[2-([[3-bromo-6-(hydroxy-kappaO)cyclohexa-2,4-dien-1-yl]methylidene]amino-kappaN)benzoato(2-)-kappaO]cuprate(1-)
-
 Rattus norvegicus
aqua[2-([[3-chloro-6-(hydroxy-kappaO)cyclohexa-2,4-dien-1-yl]methylidene]amino-kappaN)benzoato(2-)-kappaO]cuprate(1-)
-
 Rattus norvegicus
bis[4-chloro-2-[(phenylimino-kappaN)methyl]phenolato-kappaO]copper
-
 Rattus norvegicus
bis[4-nitro-2-[(phenylimino-kappaN)methyl]phenolato-kappaO]copper
-
 Rattus norvegicus
Cu2+
-
 Rattus norvegicus
diaqua[2-chloro-6-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]-4-(hydroxymethyl)phenolato-kappaO](2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)copper
-
 Rattus norvegicus
diaqua[3-([[2-(carboxy-kappaO)phenyl]imino-kappaN]methyl)-4-(hydroxy-kappaO)cyclohexa-1,5-dien-1-yl](hydroxy)oxoammoniumato(2-)copper
-
 Rattus norvegicus
protein-binding copper complex 10
-
 Rattus norvegicus
protein-binding copper complex 11
-
 Rattus norvegicus
protein-binding copper complex 9
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate + 2-oxoglutarate Rattus norvegicus
-
 oxaloacetate + L-glutamate
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
SP-Sepharose column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate + 2-oxoglutarate
-
 Rattus norvegicus oxaloacetate + L-glutamate
-
 r

Subunits

Subunits Comment Organism
? x * 47680, calculated from amino acid sequence Rattus norvegicus

Synonyms

Synonyms Comment Organism
aspartate aminotransferase
-
 Rattus norvegicus
AST
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus

pI Value

Organism Comment pI Value Maximum pI Value
Rattus norvegicus calculated from amino acid sequence
-
 9.1

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0036
-
 at pH 7.5 and 37°C Rattus norvegicus (2-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)(2-hydroxyethyl)(2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)cuprate(1-)
0.0072
-
 at pH 7.5 and 37°C Rattus norvegicus (2-chloro-6-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)(2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)copper
0.008
-
 at pH 7.5 and 37°C Rattus norvegicus Cu2+
0.008
-
 at pH 7.5 and 37°C Rattus norvegicus protein-binding copper complex 11
0.012
-
 at pH 7.5 and 37°C Rattus norvegicus bis[4-chloro-2-[(phenylimino-kappaN)methyl]phenolato-kappaO]copper
0.017
-
 at pH 7.5 and 37°C Rattus norvegicus bis[4-nitro-2-[(phenylimino-kappaN)methyl]phenolato-kappaO]copper
0.053
-
 at pH 7.5 and 37°C Rattus norvegicus diaqua[2-chloro-6-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]-4-(hydroxymethyl)phenolato-kappaO](2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)copper
0.072
-
 at pH 7.5 and 37°C Rattus norvegicus diaqua[3-([[2-(carboxy-kappaO)phenyl]imino-kappaN]methyl)-4-(hydroxy-kappaO)cyclohexa-1,5-dien-1-yl](hydroxy)oxoammoniumato(2-)copper
0.078
-
 at pH 7.5 and 37°C Rattus norvegicus aqua[2-([[3-bromo-6-(hydroxy-kappaO)cyclohexa-2,4-dien-1-yl]methylidene]amino-kappaN)benzoato(2-)-kappaO]cuprate(1-)
0.089
-
 at pH 7.5 and 37°C Rattus norvegicus aqua[2-([[3-chloro-6-(hydroxy-kappaO)cyclohexa-2,4-dien-1-yl]methylidene]amino-kappaN)benzoato(2-)-kappaO]cuprate(1-)
1
-
 at pH 7.5 and 37°C Rattus norvegicus protein-binding copper complex 10
1
-
 at pH 7.5 and 37°C Rattus norvegicus protein-binding copper complex 9