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Literature summary for 2.6.1.107 extracted from

  • Huang, Y.T.; Lyu, S.Y.; Chuang, P.H.; Hsu, N.S.; Li, Y.S.; Chan, H.C.; Huang, C.J.; Liu, Y.C.; Wu, C.J.; Yang, W.B.; Li, T.L.
    In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin (2009), ChemBioChem, 10, 2480-2487.
    View publication on PubMed
Search for more literature for 2.6.1.107

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces hygroscopicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate Streptomyces hygroscopicus the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin (3S)-2-oxo-3-phenylbutanoate + L-glutamate
-
 ?
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate Streptomyces hygroscopicus NRRL3085 the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin (3S)-2-oxo-3-phenylbutanoate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces hygroscopicus Q643C8
-
-
Streptomyces hygroscopicus NRRL3085 Q643C8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate
-
 Streptomyces hygroscopicus (3S)-2-oxo-3-phenylbutanoate + L-glutamate
-
 ?
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin Streptomyces hygroscopicus (3S)-2-oxo-3-phenylbutanoate + L-glutamate
-
 ?
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate
-
 Streptomyces hygroscopicus NRRL3085 (3S)-2-oxo-3-phenylbutanoate + L-glutamate
-
 ?
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin Streptomyces hygroscopicus NRRL3085 (3S)-2-oxo-3-phenylbutanoate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
TyrB
-
 Streptomyces hygroscopicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Streptomyces hygroscopicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Streptomyces hygroscopicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate required Streptomyces hygroscopicus

General Information

General Information Comment Organism
physiological function the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin Streptomyces hygroscopicus