Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glycine | - |
Rattus norvegicus | |
homoserine | asparagine/pyruvate reaction; DL-isomer | Rattus norvegicus | |
L-2-aminobutanoate | weak, asparagine/pyruvate reaction | Rattus norvegicus | |
L-alanine | weak, asparagine/pyruvate reaction | Rattus norvegicus | |
L-aspartate | - |
Rattus norvegicus | |
L-glutamine | - |
Rattus norvegicus | |
L-methionine-SR-sulfoxime | asparagine/pyruvate reaction | Rattus norvegicus | |
leucine | asparagine/pyruvate reaction; weak | Rattus norvegicus | |
methionine | asparagine/pyruvate reaction; L-isomer | Rattus norvegicus | |
S-methyl-L-cysteine | asparagine/pyruvate reaction | Rattus norvegicus | |
serine | asparagine/pyruvate reaction | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.077 | - |
glyoxylate | cosubstrate L-asparagine | Rattus norvegicus | |
0.35 | - |
4-methylsulfanyl-2-oxobutanoate | cosubstrate L-asparagine | Rattus norvegicus | |
0.45 | - |
phenylpyruvate | cosubstrate L-asparagine | Rattus norvegicus | |
2.5 | - |
2-oxosuccinamate | cosubstrate L-asparagine | Rattus norvegicus | |
5.1 | - |
pyruvate | cosubstrate L-asparagine | Rattus norvegicus | |
100 | - |
2-oxobutanoate | cosubstrate L-asparagine | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glyoxylate + amino acid | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-asparagine + a 2-oxo carboxylate = 2-oxosuccinamate + an amino acid | ping-pong mechanism | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
similar activity in glycylglycine, ammediol and Tris/HCl buffer | Rattus norvegicus |
0.25 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxosuccinamic acid + aspartate | - |
Rattus norvegicus | L-asparagine + 2-oxo-propane-1,3-dioate | - |
? | |
2-oxosuccinamic acid + L-2-aminobutanoic acid | - |
Rattus norvegicus | L-asparagine + 2-oxobutanoate | - |
r | |
2-oxosuccinamic acid + L-alanine | - |
Rattus norvegicus | L-asparagine + pyruvate | - |
? | |
2-oxosuccinamic acid + L-cysteine | - |
Rattus norvegicus | L-asparagine + 3-mercapto-2-oxopropanoate | - |
? | |
2-oxosuccinamic acid + L-glutamine | - |
Rattus norvegicus | L-asparagine + L-glutamate | - |
? | |
2-oxosuccinamic acid + L-homoserine | - |
Rattus norvegicus | L-asparagine + 4-hydroxy-2-oxobutanoate | - |
? | |
2-oxosuccinamic acid + L-leucine | - |
Rattus norvegicus | L-asparagine + 4-methyl-2-oxopentanoate | - |
? | |
2-oxosuccinamic acid + L-methionine | - |
Rattus norvegicus | L-asparagine + 4-methylsulfanyl-2-oxobutanoate | - |
r | |
2-oxosuccinamic acid + L-methylcysteine | - |
Rattus norvegicus | L-asparagine + ? | - |
? | |
2-oxosuccinamic acid + L-phenylalanine | - |
Rattus norvegicus | L-asparagine + 2-oxo-3-phenylpropanoate | - |
? | |
2-oxosuccinamic acid + L-serine | - |
Rattus norvegicus | L-asparagine + 3-hydroxy-2-oxopropanoate | - |
? | |
glyoxylate + amino acid | - |
Rattus norvegicus | ? | - |
? | |
glyoxylate + L-asparagine | - |
Rattus norvegicus | ? + 2-oxosuccinamate | - |
? | |
L-asparagine + 2-oxobutanoate | weak | Rattus norvegicus | 2-oxosuccinamate + 2-aminobutanoate | - |
r | |
L-asparagine + 2-oxosuccinamate | - |
Rattus norvegicus | 2-oxosuccinamate + L-asparagine | - |
? | |
L-asparagine + 4-methylsulfanyl-2-oxobutanoate | - |
Rattus norvegicus | 2-oxosuccinamate + L-methionine | - |
r | |
L-asparagine + glyoxylate | - |
Rattus norvegicus | 2-oxosuccinamate + glycine | - |
? | |
L-asparagine + pyruvate | - |
Rattus norvegicus | 2-oxosuccinamate + L-alanine | - |
? | |
additional information | the following 2-oxo acids are inactive at concentrations of 20 mM: 2-oxoglutarate, oxaloacetate, 2-oxoisopentanoate, L-2-oxo-3-methylvalerate, 3-sulfopyruvate, 3-hydroxy-2-oxobutanoate, trimethylpyruvate | Rattus norvegicus | ? | - |
? | |
phenylpyruvate + L-asparagine | - |
Rattus norvegicus | L-phenylalanine + 2-oxosuccinamate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | 8.6 | - |
Rattus norvegicus |