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Literature summary for 2.6.1.14 extracted from

  • Cooper, A.J.L.
    Asparagine transaminase from rat liver (1977), J. Biol. Chem., 252, 2032-2038.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glycine
-
Rattus norvegicus
homoserine asparagine/pyruvate reaction; DL-isomer Rattus norvegicus
L-2-aminobutanoate weak, asparagine/pyruvate reaction Rattus norvegicus
L-alanine weak, asparagine/pyruvate reaction Rattus norvegicus
L-aspartate
-
Rattus norvegicus
L-glutamine
-
Rattus norvegicus
L-methionine-SR-sulfoxime asparagine/pyruvate reaction Rattus norvegicus
leucine asparagine/pyruvate reaction; weak Rattus norvegicus
methionine asparagine/pyruvate reaction; L-isomer Rattus norvegicus
S-methyl-L-cysteine asparagine/pyruvate reaction Rattus norvegicus
serine asparagine/pyruvate reaction Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.077
-
glyoxylate cosubstrate L-asparagine Rattus norvegicus
0.35
-
4-methylsulfanyl-2-oxobutanoate cosubstrate L-asparagine Rattus norvegicus
0.45
-
phenylpyruvate cosubstrate L-asparagine Rattus norvegicus
2.5
-
2-oxosuccinamate cosubstrate L-asparagine Rattus norvegicus
5.1
-
pyruvate cosubstrate L-asparagine Rattus norvegicus
100
-
2-oxobutanoate cosubstrate L-asparagine Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glyoxylate + amino acid Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
L-asparagine + a 2-oxo carboxylate = 2-oxosuccinamate + an amino acid ping-pong mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
similar activity in glycylglycine, ammediol and Tris/HCl buffer Rattus norvegicus
0.25
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxosuccinamic acid + aspartate
-
Rattus norvegicus L-asparagine + 2-oxo-propane-1,3-dioate
-
?
2-oxosuccinamic acid + L-2-aminobutanoic acid
-
Rattus norvegicus L-asparagine + 2-oxobutanoate
-
r
2-oxosuccinamic acid + L-alanine
-
Rattus norvegicus L-asparagine + pyruvate
-
?
2-oxosuccinamic acid + L-cysteine
-
Rattus norvegicus L-asparagine + 3-mercapto-2-oxopropanoate
-
?
2-oxosuccinamic acid + L-glutamine
-
Rattus norvegicus L-asparagine + L-glutamate
-
?
2-oxosuccinamic acid + L-homoserine
-
Rattus norvegicus L-asparagine + 4-hydroxy-2-oxobutanoate
-
?
2-oxosuccinamic acid + L-leucine
-
Rattus norvegicus L-asparagine + 4-methyl-2-oxopentanoate
-
?
2-oxosuccinamic acid + L-methionine
-
Rattus norvegicus L-asparagine + 4-methylsulfanyl-2-oxobutanoate
-
r
2-oxosuccinamic acid + L-methylcysteine
-
Rattus norvegicus L-asparagine + ?
-
?
2-oxosuccinamic acid + L-phenylalanine
-
Rattus norvegicus L-asparagine + 2-oxo-3-phenylpropanoate
-
?
2-oxosuccinamic acid + L-serine
-
Rattus norvegicus L-asparagine + 3-hydroxy-2-oxopropanoate
-
?
glyoxylate + amino acid
-
Rattus norvegicus ?
-
?
glyoxylate + L-asparagine
-
Rattus norvegicus ? + 2-oxosuccinamate
-
?
L-asparagine + 2-oxobutanoate weak Rattus norvegicus 2-oxosuccinamate + 2-aminobutanoate
-
r
L-asparagine + 2-oxosuccinamate
-
Rattus norvegicus 2-oxosuccinamate + L-asparagine
-
?
L-asparagine + 4-methylsulfanyl-2-oxobutanoate
-
Rattus norvegicus 2-oxosuccinamate + L-methionine
-
r
L-asparagine + glyoxylate
-
Rattus norvegicus 2-oxosuccinamate + glycine
-
?
L-asparagine + pyruvate
-
Rattus norvegicus 2-oxosuccinamate + L-alanine
-
?
additional information the following 2-oxo acids are inactive at concentrations of 20 mM: 2-oxoglutarate, oxaloacetate, 2-oxoisopentanoate, L-2-oxo-3-methylvalerate, 3-sulfopyruvate, 3-hydroxy-2-oxobutanoate, trimethylpyruvate Rattus norvegicus ?
-
?
phenylpyruvate + L-asparagine
-
Rattus norvegicus L-phenylalanine + 2-oxosuccinamate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5 8.6
-
Rattus norvegicus