Literature summary for 2.6.1.16 extracted from

Kikuchi, H.; Ikeda, Y.; Tsuiki, S.
Inhibition of L-glutamine:D-fructose-6-phosphate aminotransferase by methylglyoxal (1972), Biochim. Biophys. Acta, 289, 303-310.

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Inhibitors

Inhibitors	Comment	Organism	Structure
dihydroxyacetone	weak	Rattus norvegicus
dihydroxyacetone phosphate	weak	Rattus norvegicus
fructose 1,6-diphosphate	weak	Rattus norvegicus
glyceraldehyde 3-phosphate	50% inhibition at 0.2 mM	Rattus norvegicus
glycolaldehyde	weak	Rattus norvegicus
Glyoxal	50% inhibition at 0.03 mM	Rattus norvegicus
L-alpha-glycerophosphate	weak	Rattus norvegicus
methylglyoxal	50% inhibition at 0.01 mM, non competitive	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	rat	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamine + D-fructose 6-phosphate	-	Rattus norvegicus	L-glutamate + D-glucosamine 6-phosphate	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

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Release 2023.1 (January 2023)