Literature summary for 2.6.1.16 extracted from

Milewski, S.; Chmara, H.; Andruszkiewicz, R.; Borowski, E.
N3-haloacetyl derivatives of L-2,3-diaminopropanoic acid: novel inactivators of glucosamine-6-phosphate synthase (1992), Biochim. Biophys. Acta, 1115, 225-229.

Search for more literature for 2.6.1.16

Inhibitors

Inhibitors	Comment	Organism	Structure
L-2,3-diaminopropanoic acid	-	Bacillus pumilus
L-2,3-diaminopropanoic acid	-	Candida albicans
L-2,3-diaminopropanoic acid	-	Escherichia coli
N3-bromoacetyl-L-2,3-diaminopropanoic acid	competitive with respect to L-glutamine	Bacillus pumilus
N3-bromoacetyl-L-2,3-diaminopropanoic acid	competitive with respect to L-glutamine	Candida albicans
N3-bromoacetyl-L-2,3-diaminopropanoic acid	competitive with respect to L-glutamine	Escherichia coli
N3-chloroacetyl-L-2,3-diaminopropanoic acid	competitive with respect to L-glutamine	Bacillus pumilus
N3-chloroacetyl-L-2,3-diaminopropanoic acid	competitive with respect to L-glutamine	Candida albicans
N3-chloroacetyl-L-2,3-diaminopropanoic acid	competitive with respect to L-glutamine	Escherichia coli
N3-iodoacetyl-L-2,3-diaminopropanoic acid	competitive with respect to L-glutamine	Bacillus pumilus
N3-iodoacetyl-L-2,3-diaminopropanoic acid	competitive with respect to L-glutamine	Candida albicans
N3-iodoacetyl-L-2,3-diaminopropanoic acid	competitive with respect to L-glutamine	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Bacillus pumilus	-	-	-
Candida albicans	-	-	-
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamine + D-fructose 6-phosphate	-	Escherichia coli	L-glutamate + D-glucosamine 6-phosphate	-	?
L-glutamine + D-fructose 6-phosphate	-	Candida albicans	L-glutamate + D-glucosamine 6-phosphate	-	?
L-glutamine + D-fructose 6-phosphate	-	Bacillus pumilus	L-glutamate + D-glucosamine 6-phosphate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0001	-	N3-bromoacetyl-L-2,3-diaminopropanoic acid	pH 6.5, 25°C	Candida albicans
0.000125	-	N3-iodoacetyl-L-2,3-diaminopropanoic acid	pH 6.5, 25°C	Candida albicans
0.0006	-	N3-chloroacetyl-L-2,3-diaminopropanoic acid	pH 6.5, 25°C	Candida albicans

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Release 2023.1 (January 2023)