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Literature summary for 2.6.1.19 extracted from

  • Iftikhar, H.; Batool, S.; Deep, A.; Narasimhan, B.; Sharma, P.; Malhotra, M.
    In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase (2017), Arab. J. Chem., 10, S1267-S1275 .
No PubMed abstract available
Search for more literature for 2.6.1.19

Inhibitors

Inhibitors Comment Organism Structure
4-(1,3-dioxoisoindolin-2-yl)-N-(4-ethylphenyl)butanamide
-
 Homo sapiens
4-(1,3-dioxoisoindolin-2-yl)-N-(4-ethylphenyl)butanamide
-
 Sus scrofa
4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorophenyl)butanamide
-
 Homo sapiens
4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorophenyl)butanamide
-
 Sus scrofa
4-(1,3-dioxoisoindolin-2-yl)-N-(4-iodophenyl)butanamide
-
 Homo sapiens
4-(1,3-dioxoisoindolin-2-yl)-N-(4-iodophenyl)butanamide
-
 Sus scrofa
4-(1,3-dioxoisoindolin-2-yl)-N-(4-methoxyphenyl)butanamide
-
 Homo sapiens
4-(1,3-dioxoisoindolin-2-yl)-N-(4-methoxyphenyl)butanamide
-
 Sus scrofa
4-(1,3-dioxoisoindolin-2-yl)-N-(4-nitrophenyl)butanamide
-
 Homo sapiens
4-(1,3-dioxoisoindolin-2-yl)-N-(4-nitrophenyl)butanamide
-
 Sus scrofa
4-(1,3-dioxoisoindolin-2-yl)-N-p-tolylbutanamide
-
 Homo sapiens
4-(1,3-dioxoisoindolin-2-yl)-N-p-tolylbutanamide
-
 Sus scrofa
4-(1,3-dioxoisoindolin-2-yl)-N-phenylbutanamide
-
 Homo sapiens
4-(1,3-dioxoisoindolin-2-yl)-N-phenylbutanamide
-
 Sus scrofa
additional information a series of gamma-aminobutyric acid (GABA) derivatives obtained from 4-(1,3-dioxoisoindolin-2-yl)butanoic acid are synthesized and analyzed as inhibitory ligands docking against human ABAT as well as pig ABAT receptors. Active site docking study, overview Homo sapiens
additional information a series of gamma-aminobutyric acid (GABA) derivatives obtained from 4-(1,3-dioxoisoindolin-2-yl)butanoic acid are synthesized and analyzed as inhibitory ligands docking against human ABAT as well as pig ABAT receptors. Active site docking study, overview Sus scrofa
N-(2,4-dichlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
N-(2,4-dichlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa
N-(2,4-difluorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
N-(2,4-difluorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa
N-(4-bromophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
N-(4-bromophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa
N-(4-chloro-2-iodophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
N-(4-chloro-2-iodophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa
N-(4-chloro-2-methylphenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
N-(4-chloro-2-methylphenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa
N-(4-chlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Homo sapiens
N-(4-chlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Sus scrofa 5739
-
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate Sus scrofa
-
 succinate semialdehyde + L-glutamate
-
 ?
4-aminobutanoate + 2-oxoglutarate Homo sapiens
-
 succinate semialdehyde + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P80404
-
-
Sus scrofa P80147
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate
-
 Sus scrofa succinate semialdehyde + L-glutamate
-
 ?
4-aminobutanoate + 2-oxoglutarate
-
 Homo sapiens succinate semialdehyde + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
4-aminobutyrate transaminase
-
 Sus scrofa
4-aminobutyrate transaminase
-
 Homo sapiens
ABAT
-
 Sus scrofa
ABAT
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Sus scrofa
pyridoxal 5'-phosphate
-
 Homo sapiens

General Information

General Information Comment Organism
additional information homology structure modeling using pig ABAT as template (PDB ID 6B6G) Sus scrofa
additional information homology structure modeling using pig ABAT as template (PDB ID 6B6G) Homo sapiens