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Literature summary for 2.6.1.19 extracted from

  • Wang, J.X.; Mu, J.D.; Ma, L.X.; Sun, T.Y.; Qian, X.; Yu, W.Y.; Tian, Y.; Song, Y.; Gan, Y.Y.; Guo, M.W.; Ren, X.X.; Li, J.L.
    Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating gamma-aminobutyric acid transaminase and enhancing gamma-aminobutyric acid (2020), NeuroReport, 31, 708-716 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.19

Application

Application Comment Organism
medicine attenuating GABAT activity and enhancing GABA expression are a promising way to relieve spasticity following stroke. The modulation of GABA and its metabolism by acupuncture, particularly waggle needling, might attenuate GABAT and enhance GABA, alleviating post-stroke spasticity. Waggle needling decreases cerebral infarction and alleviates neurological deficits, overview. No significant difference is found between waggle needling group and baclofen group Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate Rattus norvegicus
-
 succinate semialdehyde + L-glutamate
-
 ?
4-aminobutanoate + 2-oxoglutarate Rattus norvegicus Sprague-Dawley
-
 succinate semialdehyde + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P50554
-
-
Rattus norvegicus Sprague-Dawley P50554
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate
-
 Rattus norvegicus succinate semialdehyde + L-glutamate
-
 ?
4-aminobutanoate + 2-oxoglutarate
-
 Rattus norvegicus Sprague-Dawley succinate semialdehyde + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
ABAT
-
 Rattus norvegicus
GABA transaminase
-
 Rattus norvegicus
GABAT
-
 Rattus norvegicus
gamma-aminobutyric acid transaminase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus waggle needling attenuates gamma-aminobutyric acid transaminase expression in the injured brain of rats with post-stroke spasticity down

General Information

General Information Comment Organism
malfunction inhibition of GABAT is known to boost GABA concentration in the brain and thereby alleviates spasticity. Therefore, attenuating GABAT activity and enhancing GABA expression are a promising way to relieve spasticity following stroke. Waggle needling attenuates gamma-aminobutyric acid transaminase expression in the injured brain of rats with post-stroke spasticity comparable to the effect of baclofen Rattus norvegicus
metabolism GABA transaminase (GABAT) is the key catabolic enzyme of GABA metabolism Rattus norvegicus
physiological function gamma-aminobutyric acid (GABA) is one of the chief inhibitory neurotransmitters in the central nerve system (CNS), plays pre- or postsynaptic inhibitory effects. GABA transaminase (GABAT) is the key catabolic enzyme of GABA metabolism. The modulation of GABA and its metabolism by acupuncture, particularly waggle needling, might attenuate GABAT and enhance GABA, alleviating post-stroke spasticity Rattus norvegicus