KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.19 | - |
2-oxoglutarate | pH 7.8, 30°C, mitochondrial enzyme | Homo sapiens | |
0.22 | - |
2-oxoglutarate | pH 7.8, 30°C, cytosolic enzyme | Homo sapiens | |
5.1 | - |
L-alanine | pH 7.8, 30°C, mitochondrial enzyme | Homo sapiens | |
21 | - |
alanine | pH 7.8, 30°C, cytosolic enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + 2-oxoglutarate | Homo sapiens | mitochondrial isoenzyme shows higher affinity for L-alanine, mainly functions in the direction of conversion of alanine to pyruvate whereas the cytosolic isoenzyme would function in both directions | pyruvate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate, DEAE-Sepharose, partial purification of cytosolic and mitochondrial isoenzymes | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + 2-oxoglutarate | - |
Homo sapiens | pyruvate + L-glutamate | - |
? | |
L-alanine + 2-oxoglutarate | mitochondrial isoenzyme shows higher affinity for L-alanine, mainly functions in the direction of conversion of alanine to pyruvate whereas the cytosolic isoenzyme would function in both directions | Homo sapiens | pyruvate + L-glutamate | - |
? |