Literature summary for 2.6.1.21 extracted from

Yu, Y.; Yang, J.; Zheng, L.; Sheng, Q.; Li, C.; Wang, M.; Zhang, X.; McMinn, A.; Zhang, Y.; Song, X.; Chen, X.
Diversity of D-amino acid utilizing bacteria from Kongsfjorden, Arctic, and the metabolic pathways for seven D-amino acids (2020), Front. Microbiol., 10, 2983 .

Search for more literature for 2.6.1.21

Cloned(Commentary)

Cloned (Comment)	Organism
gene FQP89_01185, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, quantitative RT-PCR enzyme expression analysis, recombinant expression in Escherichia coli strain BL21(DE3)	Halomonas titanicae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-alanine + 2-oxoglutarate	Halomonas titanicae	-	pyruvate + D-glutamate	-	r
D-alanine + 2-oxoglutarate	Halomonas titanicae SM1922	-	pyruvate + D-glutamate	-	r
D-aspartate + 2-oxoglutarate	Halomonas titanicae	-	2-oxosuccinate + D-glutamate	-	r
D-aspartate + 2-oxoglutarate	Halomonas titanicae SM1922	-	2-oxosuccinate + D-glutamate	-	r
D-leucine + 2-oxoglutarate	Halomonas titanicae	-	4-methyl-2-oxopentanoate + D-glutamate	-	r
D-methionine + 2-oxoglutarate	Halomonas titanicae	-	4-methylsulfanyl-2-oxobutanoate + D-glutamate	-	r
D-methionine + 2-oxoglutarate	Halomonas titanicae SM1922	-	4-methylsulfanyl-2-oxobutanoate + D-glutamate	-	r
D-phenylalanine + 2-oxoglutarate	Halomonas titanicae	-	phenylpyruvate + D-glutamate	-	r
D-serine + 2-oxoglutarate	Halomonas titanicae	-	3-hydroxy-2-oxopropanoate + D-glutamate	-	r
D-threonine + 2-oxoglutarate	Halomonas titanicae	-	2-oxobutanoate + D-glutamate	-	r
D-tyrosine + 2-oxoglutarate	Halomonas titanicae	-	3-(4-hydroxyphenyl)-2-oxopropanoate + D-glutamate	-	r
additional information	Halomonas titanicae	in vivo substrate specificity of strain SM1922	?	-	-
additional information	Halomonas titanicae SM1922	in vivo substrate specificity of strain SM1922	?	-	-

Organism

Organism	UniProt	Comment	Textmining
Halomonas titanicae	A0A558JDR6	-	-
Halomonas titanicae SM1922	A0A558JDR6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	relative transcriptional levels of gene FQP89_15030 (FAD-binding oxidoreductase), FQP89_01690 (DAA dehydrogenase 3 small subunit), FQP89_11185 (FAD-binding oxidoreductase) and FQP89_01185 (D-amino-acid transaminase) in strain SM1922 cultured with D-Asp (A), D-Leu (B), and D-Thr (C) as a sole nitrogen source, respectively, overview. Quantitative RT-PCR genes expression analysis	Halomonas titanicae	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-alanine + 2-oxoglutarate	-	Halomonas titanicae	pyruvate + D-glutamate	-	r
D-alanine + 2-oxoglutarate	-	Halomonas titanicae SM1922	pyruvate + D-glutamate	-	r
D-aspartate + 2-oxoglutarate	-	Halomonas titanicae	2-oxosuccinate + D-glutamate	-	r
D-aspartate + 2-oxoglutarate	-	Halomonas titanicae SM1922	2-oxosuccinate + D-glutamate	-	r
D-leucine + 2-oxoglutarate	-	Halomonas titanicae	4-methyl-2-oxopentanoate + D-glutamate	-	r
D-leucine + 2-oxoglutarate	high activity	Halomonas titanicae	4-methyl-2-oxopentanoate + D-glutamate	-	r
D-methionine + 2-oxoglutarate	-	Halomonas titanicae	4-methylsulfanyl-2-oxobutanoate + D-glutamate	-	r
D-methionine + 2-oxoglutarate	low activity	Halomonas titanicae	4-methylsulfanyl-2-oxobutanoate + D-glutamate	-	r
D-methionine + 2-oxoglutarate	-	Halomonas titanicae SM1922	4-methylsulfanyl-2-oxobutanoate + D-glutamate	-	r
D-methionine + 2-oxoglutarate	low activity	Halomonas titanicae SM1922	4-methylsulfanyl-2-oxobutanoate + D-glutamate	-	r
D-phenylalanine + 2-oxoglutarate	-	Halomonas titanicae	phenylpyruvate + D-glutamate	-	r
D-serine + 2-oxoglutarate	-	Halomonas titanicae	3-hydroxy-2-oxopropanoate + D-glutamate	-	r
D-serine + 2-oxoglutarate	best substrate	Halomonas titanicae	3-hydroxy-2-oxopropanoate + D-glutamate	-	r
D-threonine + 2-oxoglutarate	-	Halomonas titanicae	2-oxobutanoate + D-glutamate	-	r
D-tyrosine + 2-oxoglutarate	-	Halomonas titanicae	3-(4-hydroxyphenyl)-2-oxopropanoate + D-glutamate	-	r
D-tyrosine + 2-oxoglutarate	low activity	Halomonas titanicae	3-(4-hydroxyphenyl)-2-oxopropanoate + D-glutamate	-	r
additional information	in vivo substrate specificity of strain SM1922	Halomonas titanicae	?	-	-
additional information	in vivo substrate specificity of strain SM1922	Halomonas titanicae SM1922	?	-	-

Synonyms

Synonyms	Comment	Organism
D-alanine:2-oxoglutarate aminotransferase	UniProt	Halomonas titanicae
DAA aminotransferase	-	Halomonas titanicae
DAA transaminase	-	Halomonas titanicae
FQP89_01185	locus name	Halomonas titanicae
TRA-01185	-	Halomonas titanicae

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	PLP	Halomonas titanicae

General Information

General Information	Comment	Organism
evolution	diversity of D-amino acid utilizing bacteria from Kongsfjorden, Arctic, and the metabolic pathways for seven D-amino acids, analysis of key genes predicted to be involved in D-amino acid catabolism in the bacterial strains, detailed overview	Halomonas titanicae
metabolism	the enzyme is involved int he D-Ala and D-Asp metabolism in strain SM1922 of the arctic ocean bacterium. Pathways for D-Leu, D-Met, D-Phe, D-Thr, D-Tyr, D-Ser, and D-Asp metabolism in the isolated marine bacteria, overview	Halomonas titanicae

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Release 2023.1 (January 2023)