Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2-(5,6-dichloro-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-3-phenylpropanoic acid | reversible inhibitor | Homo sapiens | |
(2S)-2-amino-4-[4-(ethylsulfonyl)phenyl]-4-oxobutanoic acid | reversible inhibitor | Homo sapiens | |
(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one | irreversible inhibitor | Homo sapiens | |
(5Z)-5-[3-(4-oxo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-7-yl)benzylidene]-1,3-thiazolidine-2,4-dione | reversible inhibitor | Homo sapiens | |
(6R)-8-cyclopropyl-N-(3,5-dimethylphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | - |
Homo sapiens | |
(6R)-8-cyclopropyl-N-(4-methoxyphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | - |
Homo sapiens | |
(6R)-N-(3-chloro-4-fluorophenyl)-8-(cyclopropylmethyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | - |
Homo sapiens | |
(6R)-N-(3-ethylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | - |
Homo sapiens | |
(6S)-8-cyclopropyl-N-(3,5-dimethylphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | - |
Homo sapiens | |
(6S)-8-cyclopropyl-N-(4-methoxyphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | - |
Homo sapiens | |
(6S)-N-(3-chloro-4-fluorophenyl)-8-(cyclopropylmethyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | - |
Homo sapiens | |
(6S)-N-(3-ethylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | - |
Homo sapiens | |
3,5-difluoro-N-[5-(1-phenylcyclopropyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide | - |
Homo sapiens | |
3,5-difluoro-N-{5-[(2R)-2-(3-fluorophenyl)-3-methylbutyl]-1,3,4-thiadiazol-2-yl}benzenesulfonamide | - |
Homo sapiens | |
3,5-difluoro-N-{5-[(2S)-2-(3-fluorophenyl)-3-methylbutyl]-1,3,4-thiadiazol-2-yl}benzenesulfonamide | - |
Homo sapiens | |
3,5-difluoro-N-{5-[2-(3-fluorophenyl)-3-methylbutyl]-1,3,4-thiadiazol-2-yl}benzenesulfonamide | - |
Homo sapiens | |
4-chloro-N-(pyrrolidin-3-yl)-2-(trifluoromethyl)benzenesulfonamide | - |
Homo sapiens | |
BFF-122 | irreversible inhibitor | Homo sapiens | |
N-(3-chloro-4-methylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | - |
Homo sapiens | |
N-(3-ethylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | - |
Homo sapiens | |
N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]-D-prolinamide | reversible inhibitor | Homo sapiens | |
N-[5-(cyclopentylmethyl)-1,3,4-oxadiazol-2-yl]benzenesulfonamide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + 2-oxoglutarate | Homo sapiens | - |
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N5Z0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + 2-oxoglutarate | - |
Homo sapiens | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KAT2 | - |
Homo sapiens |
kynurenine aminotransferase 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00081 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(3-chloro-4-methylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | |
0.0024 | - |
pH and temperature not specified in the publication | Homo sapiens | (6R)-N-(3-chloro-4-fluorophenyl)-8-(cyclopropylmethyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | |
0.0045 | - |
pH and temperature not specified in the publication | Homo sapiens | (6R)-8-cyclopropyl-N-(3,5-dimethylphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | |
0.008 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(3-ethylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | |
0.0155 | - |
pH and temperature not specified in the publication | Homo sapiens | (6S)-8-cyclopropyl-N-(4-methoxyphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | |
0.044 | - |
pH and temperature not specified in the publication | Homo sapiens | (6R)-N-(3-ethylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | |
0.0749 | - |
pH and temperature not specified in the publication | Homo sapiens | (6S)-8-cyclopropyl-N-(3,5-dimethylphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | |
0.0965 | - |
pH and temperature not specified in the publication | Homo sapiens | (6S)-N-(3-chloro-4-fluorophenyl)-8-(cyclopropylmethyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | |
0.097 | - |
pH and temperature not specified in the publication | Homo sapiens | (6S)-N-(3-ethylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, pH and temperature not specified in the publication | Homo sapiens | (6R)-8-cyclopropyl-N-(4-methoxyphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide |