Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Rosetta 2 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid | - |
Homo sapiens | |
4-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenesulfonamide | reversible inhibitor | Homo sapiens | |
4-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethylbenzenesulfonamide | reversible inhibitor | Homo sapiens | |
estradiol disulfate | very strong inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + 2-oxoglutarate | Homo sapiens | - |
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate + H2O | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N5Z0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + 2-oxoglutarate | - |
Homo sapiens | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate + H2O | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
KAT-II | isoform | Homo sapiens |
kynurenine aminotransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0263 | - |
at pH 7.4 and 37°C | Homo sapiens | estradiol disulfate | |
0.0738 | - |
at pH 7.4 and 37°C | Homo sapiens | 4-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenesulfonamide | |
0.1128 | - |
at pH 7.4 and 37°C | Homo sapiens | 4-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethylbenzenesulfonamide | |
0.315 | - |
at pH 7.4 and 37°C | Homo sapiens | (2R)-2-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid |