Protein Variants | Comment | Organism |
---|---|---|
K217A | the TAA1 mutant shows a defect in pyridoxal 5'-phosphate binding | Arabidopsis thaliana |
additional information | phenotypes of multiple mutant combinations, strong ethylene defects of the wei8 tar2 roots and the typical ethylene-triggered differential growth of apical hooks is also blocked in wei8 tar2, wei8 tar2 mutants have reduced levels of auxin | Arabidopsis thaliana |
P166S | wei8-2 utant version of TAA1 | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + pyruvate | Arabidopsis thaliana | - |
indole-3-pyruvate + L-alanine | - |
? | |
L-tryptophan + pyruvate | Arabidopsis thaliana Col-0 | - |
indole-3-pyruvate + L-alanine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q9S7N2 | gene wei8 | - |
Arabidopsis thaliana Col-0 | Q9S7N2 | gene wei8 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
flower | - |
Arabidopsis thaliana | - |
leaf | - |
Arabidopsis thaliana | - |
root | - |
Arabidopsis thaliana | - |
seedling | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + pyruvate | - |
Arabidopsis thaliana | indole-3-pyruvate + L-alanine | - |
? | |
L-tryptophan + pyruvate | - |
Arabidopsis thaliana Col-0 | indole-3-pyruvate + L-alanine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TAA1 | - |
Arabidopsis thaliana |
TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS1 | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
evolution | TAA1 encodes a member of a small family of aminotransferases with strong sequence similarity to C-S Lyases | Arabidopsis thaliana |
malfunction | the ethylene defects of wei8 are dramatically enhanced in the wei8 tar2 double mutants that display a nearly complete lack of response to ACC in roots | Arabidopsis thaliana |
metabolism | gene wei8 encodes a long-anticipated tryptophan aminotransferase, TAA1, in the essential indole-3-pyruvic acid branch of the auxin biosynthetic pathway, a link between local auxin production, tissue-specific ethylene effects, and organ development exists. TAA1 and TAR2 have overlapping roles in the ethylene response, overview | Arabidopsis thaliana |
physiological function | gene wei8 encodes a long-anticipated tryptophan aminotransferase, TAA1, in the essential indole-3-pyruvic acid branch of the auxin biosynthetic pathway, a link between local auxin production, tissue-specific ethylene effects, and organ development exists. The IPA route of auxin production is key to generating robust auxin gradients in response to environmental and developmental cues. Proper gynoecium development requires TAA1 and TAR2 function | Arabidopsis thaliana |