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Literature summary for 2.7.1.106 extracted from
- Inhibitors of glucose-1,6-bisphosphate synthase (1977), J. Biol. Chem., 252, 4262-4268.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cis/trans-aconitate | - |
Bos taurus |  |
| citrate | - |
Bos taurus | |
| D-fructose 1,6-diphosphate | - |
Bos taurus | |
| D-glucose 1,6-diphosphate | - |
Bos taurus | |
| Glutarate | weak | Bos taurus | |
| glycerate 2,3-diphosphate | - |
Bos taurus | |
| Glycerate 3-phosphate | - |
Bos taurus | |
| isocitrate | - |
Bos taurus | |
| K+ | weak | Bos taurus | |
| L-malate | weak | Bos taurus | |
| Li+ | strong, dilution, Co2+ or Zn2+ protects, not Ca2+, Mg2+ or Mn2+ | Bos taurus | |
| additional information | no inhibition by adipate or succinate | Bos taurus | |
| Na+ | weak | Bos taurus | |
| phosphate | - |
Bos taurus | |
| phosphoenolpyruvate | strong | Bos taurus | |
| tricarballylate | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000087 | - |
3-phospho-D-glyceroyl 1-phosphate | 23°C, pH 8, Mg2+-enzyme in brain | Bos taurus | |
| 0.000091 | - |
3-phospho-D-glyceroyl 1-phosphate | 23°C, pH 8, Zn2+-enzyme in brain | Bos taurus | |
| 0.09 | - |
D-glucose 1-phosphate | 23°C, pH 8, Mg2+- and Zn2+-enzyme in brain | Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | tightly bound, can replace Zn2+ | Bos taurus | |
| Mg2+ | no activation of enzyme in Zn-form | Bos taurus | |
| Mg2+ | activation, easily dissociates from enzyme protein | Bos taurus | |
| Mg2+ | Km-value: 1 mM | Bos taurus | |
| Zn2+ | Zn-form of the enzyme: tightly bound, about 65% of brain enzyme in Zn-form | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate | - |
Bos taurus | 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate | - |
r | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Bos taurus |
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Release 2023.1 (January 2023)
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