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Literature summary for 2.7.1.20 extracted from

  • Long, M.C.; Shaddix, S.C.; Moukha-Chafiq, O.; Maddry, J.A.; Nagy, L.; Parker, W.B.
    Structure-activity relationship for adenosine kinase from Mycobacterium tuberculosis II. Modifications to the ribofuranosyl moiety (2008), Biochem. Pharmacol., 75, 1588-1600.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2',3',5'-tri-O-acetyl-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
2'-deoxy-2,2'-difluoro-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
2'-deoxy-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
2'-O-methyl-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
2-chloro-2'-deoxy-2'-fluoro-9-[beta-D-arabinofuranosyl]-adenine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
2-chloro-2'-deoxy-2'-fluoro-adenosine 10-90% inhibition at 0.01 mM Mycobacterium tuberculosis
2-chloro-2'-deoxy-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
2-chloro-4'-thio-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
2-chloro-adenosine 10-90% inhibition at 0.01 mM Mycobacterium tuberculosis
2-fluoro-9-[beta-D-arabinofuranosyl]-adenine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
2-fluoro-adenosine 10-90% inhibition at 0.1 mM Homo sapiens
2-fluoro-adenosine 10-90% inhibition at 0.001 mM, competitive inhibitor Mycobacterium tuberculosis
2-methyl-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
3'-deoxy-3'-azido-adenosine 10-90% inhibition at 0.1 mM Homo sapiens
3-[beta-D-ribofuranosyl]-adenine 10-90% inhibition at 0.01 mM Mycobacterium tuberculosis
5'-amino-5'-deoxy-adenosine 10-90% inhibition at 0.001 mM Homo sapiens
5'-amino-5'-deoxy-adenosine 10-90% inhibition at 0.001 mM, competitive inhibitor Mycobacterium tuberculosis
5'-carboxamido-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
5'-deoxy-adenosine 10-90% inhibition at 0.01 mM Mycobacterium tuberculosis
6-methyl-purine riboside 10-90% inhibition at 0.01 mM Mycobacterium tuberculosis
7-deaza-carbocyclic-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
7-[alpha-D-arabinofuranosyl]-adenine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
7-[alpha-D-ribofuranosyl]-adenine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
8-aza-2'-deoxy-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
8-aza-8-[beta-D-ribofuranosyl]-adenine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
8-aza-adenosine 10-90% inhibition at 0.01 mM, competitive inhibitor Mycobacterium tuberculosis
8-aza-carbocyclic-adenosine 10-90% inhibition at 0.1 mM Homo sapiens
8-aza-carbocyclic-adenosine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
9-(2-deoxy-beta-D-erythropentopyranosyl)-adenine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
9-[alpha-D-ribofuranosyl]-adenine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
9-[alpha-L-lyxofuranosyl]-2-fluoro-adenine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
9-[alpha-L-lyxofuranosyl]-adenine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
9-[beta-D-5-methyl-(allo)-ribofuranosyl]-2-fluoro-adenine 10-90% inhibition at 0.01 mM Mycobacterium tuberculosis
9-[beta-D-5-methyl-(allo)-ribofuranosyl]-6-methyl-purine 10-90% inhibition at 0.01 mM Mycobacterium tuberculosis
9-[beta-D-5-methyl-(talo)-ribofuranosyl]-2-fluoro-adenine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
9-[beta-D-5-methyl-(talo)-ribofuranosyl]-6-methyl-purine 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis
aristeromycin 10-90% inhibition at 0.1 mM Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mycobacterium tuberculosis P9WID5
-
-
Mycobacterium tuberculosis H37Rv P9WID5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxy-2,2'-difluoro-adenosine 0.5% of the activity with adenosine Mycobacterium tuberculosis ADP + 2'-deoxy-2,2'-difluoro-AMP
-
?
ATP + 2'-deoxy-2,2'-difluoro-adenosine 0.5% of the activity with adenosine Mycobacterium tuberculosis H37Rv ADP + 2'-deoxy-2,2'-difluoro-AMP
-
?
ATP + 2'-deoxy-adenosine 3% of the activity with adenosine Homo sapiens ?
-
?
ATP + 2'-deoxy-adenosine 0.3% of the activity with adenosine Mycobacterium tuberculosis ADP + 2'-deoxy-AMP
-
?
ATP + 2'-deoxy-adenosine 0.3% of the activity with adenosine Mycobacterium tuberculosis H37Rv ADP + 2'-deoxy-AMP
-
?
ATP + 2-amino-carbocyclic-adenosine 35.8% of the activity with adenosine Homo sapiens ?
-
?
ATP + 2-amino-carbocyclic-adenosine 0.4% of the activity with adenosine Mycobacterium tuberculosis ADP + 2-amino-carbocyclic-AMP
-
?
ATP + 2-amino-carbocyclic-adenosine 0.4% of the activity with adenosine Mycobacterium tuberculosis H37Rv ADP + 2-amino-carbocyclic-AMP
-
?
ATP + 2-chloro-adenosine 0.7% of the activity with adenosine Homo sapiens ?
-
?
ATP + 2-chloro-adenosine 11.5% of the activity with adenosine Mycobacterium tuberculosis ADP + 2-chloro-AMP
-
?
ATP + 2-chloro-adenosine 11.5% of the activity with adenosine Mycobacterium tuberculosis H37Rv ADP + 2-chloro-AMP
-
?
ATP + 2-fluoro-9-[beta-D-arabinofuranosyl]-adenine 0.9% of the activity with adenosine Mycobacterium tuberculosis ADP + 2-fluoro-9-[beta-D-arabinofuranosyl]-AMP
-
?
ATP + 2-fluoro-adenosine 75% of the activity with adenosine Homo sapiens ?
-
?
ATP + 2-fluoro-adenosine 52% of the activity with adenosine Mycobacterium tuberculosis ADP + 2-fluoro-AMP
-
?
ATP + 2-methyl-adenosine 0.14% of the activity with adenosine Homo sapiens ?
-
?
ATP + 2-methyl-adenosine 2% of the activity with adenosine Mycobacterium tuberculosis ADP + 2-methyl-AMP
-
?
ATP + 3-[beta-D-ribofuranosyl]-adenine 11.2% of the activity with adenosine Homo sapiens ?
-
?
ATP + 3-[beta-D-ribofuranosyl]-adenine 0.7% of the activity with adenosine Mycobacterium tuberculosis ADP + 3-[beta-D-ribofuranosyl]-AMP
-
?
ATP + 6-methyl-purine riboside 41% of the activity with adenosine Homo sapiens ?
-
?
ATP + 6-methyl-purine riboside 2.75% of the activity with adenosine Mycobacterium tuberculosis ADP + 6-methylpurine-D-riboside 5'-phosphate
-
?
ATP + 8-aza-adenosine 38% of the activity with adenosine Homo sapiens ?
-
?
ATP + 8-aza-adenosine 4% of the activity with adenosine Mycobacterium tuberculosis ADP + 8-aza-AMP
-
?
ATP + 8-aza-carbocyclic-adenosine 26% of the activity with adenosine Homo sapiens ?
-
?
ATP + 8-aza-carbocyclic-adenosine 4% of the activity with adenosine Mycobacterium tuberculosis ADP + 8-aza-carbocyclic-AMP
-
?
ATP + 9-[alpha-L-lyxofuranosyl]-2-fluoro-adenine 3.3% of the activity with adenosine Mycobacterium tuberculosis ADP + 9-[alpha-L-lyxofuranosyl]-2-fluoro-AMP
-
?
ATP + 9-[alpha-L-lyxofuranosyl]-adenine 15% of the activity with adenosine Homo sapiens ?
-
?
ATP + 9-[alpha-L-lyxofuranosyl]-adenine 3.8% of the activity with adenosine Mycobacterium tuberculosis ADP + 9-[alpha-L-lyxofuranosyl]-AMP
-
?
ATP + 9-[beta-D-5-methyl-(allo)-ribofuranosyl]-2-fluoro-adenine 0.1% of the activity with adenosine Mycobacterium tuberculosis ADP + 9-[beta-D-5-methyl-(allo)-ribofuranosyl]-2-fluoro-AMP
-
?
ATP + 9-[beta-D-arabinofuranosyl]-adenine 0.25% of the activity with adenosine Homo sapiens ?
-
?
ATP + 9-[beta-D-arabinofuranosyl]-adenine 0.6% of the activity with adenosine Mycobacterium tuberculosis ADP + 9-[beta-D-arabinofuranosyl]-adenine 5'-phosphate
-
?
ATP + adenosine
-
Homo sapiens ADP + AMP
-
?
ATP + adenosine
-
Mycobacterium tuberculosis ADP + AMP
-
?
ATP + adenosine
-
Mycobacterium tuberculosis H37Rv ADP + AMP
-
?
ATP + aristeromycin 37% of the activity with adenosine Homo sapiens ?
-
?
ATP + aristeromycin 37.5% of the activity with adenosine Mycobacterium tuberculosis ADP + aristeromycin 5'-phosphate
-
?

Synonyms

Synonyms Comment Organism
Ado kinase
-
Homo sapiens
Ado kinase
-
Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0005
-
2-fluoro-adenosine
-
Mycobacterium tuberculosis
0.0008
-
5'-amino-5'-deoxy-adenosine
-
Mycobacterium tuberculosis