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Literature summary for 2.7.1.21 extracted from
- Deoxythymidine kinase of Escherichia coli. II. Kinetics and feedback control (1964), J. Biol. Chem., 239, 275-284.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bromo-dUTP | - |
Escherichia coli |  |
| dTTP | 50-90% inhibition at 0.2-0.8 mM; competitive to thymidine | Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Escherichia coli | |
| Mn2+ | - |
Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + thymidine | ATP can be substituted by GTP | Escherichia coli | ADP + dTMP | - |
? | |
| ATP + thymidine | ATP can be substituted by dGTP | Escherichia coli | ADP + dTMP | - |
? | |
| ATP + thymidine | requirement for high levels of ATP | Escherichia coli | ADP + dTMP | - |
? | |
| ATP + thymidine | ATP can be substituted by dATP | Escherichia coli | ADP + dTMP | - |
? | |
| ATP + thymidine | ATP can be substituted by CTP | Escherichia coli | ADP + dTMP | - |
? | |
| ATP + thymidine | ATP can be substituted by ITP | Escherichia coli | ADP + dTMP | - |
? | |
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Release 2023.1 (January 2023)
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