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Literature summary for 2.7.1.23 extracted from

  • Garavaglia, S.; Galizzi, A.; Rizzi, M.
    Allosteric regulation of Bacillus subtilis NAD kinase by quinolinic acid (2003), J. Bacteriol., 185, 4844-4850.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
quinolinic acid allosteric activator Bacillus subtilis

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Bacillus subtilis

Inhibitors

Inhibitors Comment Organism Structure
HgCl2 1 mM, 75% inhibition Bacillus subtilis
NADP+ 0.05 mM, 75% inhibition Bacillus subtilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1
-
NAD+
-
Bacillus subtilis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
2 * 30000, SDS-PAGE Bacillus subtilis
60000
-
gel filtration Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NAD+ Bacillus subtilis key enzyme for NADP+ metabolism and quinolinic acid metabolism ADP + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NAD+
-
Bacillus subtilis ADP + NADP+
-
?
ATP + NAD+ key enzyme for NADP+ metabolism and quinolinic acid metabolism Bacillus subtilis ADP + NADP+
-
?
dATP + NAD+ 77% of the activity with ATP Bacillus subtilis dADP + NADP+
-
?
dCTP + NAD+ 30% of the activity with ATP Bacillus subtilis dCDP + NADP+
-
?
dGTP + NAD+ 77% of the activity with ATP Bacillus subtilis dGDP + NADP+
-
?
diphosphate + NAD+ 10% of the activity with ATP Bacillus subtilis phosphate + NADP+
-
?
dTTP + NAD+ 35% of the activity with ATP Bacillus subtilis dTDP + NADP+
-
?
GTP + NAD+ 69% of the activity with ATP Bacillus subtilis GDP + NADP+
-
?
polyphosphate + NAD+ 50% of the activity with ATP Bacillus subtilis ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 30000, SDS-PAGE Bacillus subtilis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
-
Bacillus subtilis

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 50 25°C: about 45% of maximal activity, 50°C: about 70% of maximal activity Bacillus subtilis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
40
-
15 min, 50% loss of activity Bacillus subtilis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.36
-
ATP
-
Bacillus subtilis
5.46
-
NAD+
-
Bacillus subtilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
glycine-NaOH buffer Bacillus subtilis

pH Range

pH Minimum pH Maximum Comment Organism
7 10 pH 7.0: about 35% of maximal activity, pH 10.0: about 50% of maximal activity Bacillus subtilis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Bacillus subtilis