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Literature summary for 2.7.1.32 extracted from

  • Rodriguez-Gonzalez, A.; Ramirez de Molina, A.; Benitez-Rajal, J.; Lacal, J.C.
    Phospholipase D and choline kinase: their role in cancer development and their potential as drug targets (2003), Prog. Cell Cycle Res., 5, 191-201.
    View publication on PubMed
Search for more literature for 2.7.1.32

Application

Application Comment Organism
medicine potential target for anti-tumor drugs, potential use of the enzyme level as tumor marker Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid)
-
 Homo sapiens
5,5'-dithiobis(2-nitrobenzoic acid)
-
 Mus musculus
adenosine competitive with MgATP2- Homo sapiens
adenosine competitive with MgATP2- Mus musculus
Choline analogues several compounds tested and found to be inhibitory Homo sapiens
Choline analogues several compounds tested and found to be inhibitory Mus musculus
hemicholinium HC-3 Homo sapiens
hemicholinium HC-3 Mus musculus
KF
-
 Homo sapiens
KF
-
 Mus musculus
N-ethylmaleimide
-
 Homo sapiens
N-ethylmaleimide
-
 Mus musculus
stearoyl-CoA
-
 Homo sapiens
stearoyl-CoA
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
cytosol
-
 Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus
Mg2+ required Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
 subtype beta, mainly dimers and tetramers, x * 42000 Mus musculus
50000
-
 mainly dimers and tetramers, x * 50000 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + choline Mus musculus initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction ADP + O-phosphocholine
-
 ?
ATP + choline Homo sapiens initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction, the product O-phosphocholine serves as second messenger and is essential for cell growth, enzyme plays a role in tumor generation ADP + O-phosphocholine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y259
-
-
Mus musculus Q54AG5 subtype alpha
-
Mus musculus Q54AG5 subtype beta
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + choline
-
 Mus musculus ADP + O-phosphocholine
-
 ?
ATP + choline
-
 Homo sapiens ADP + O-phosphocholine
-
 ?
ATP + choline initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction Mus musculus ADP + O-phosphocholine
-
 ?
ATP + choline initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction, the product O-phosphocholine serves as second messenger and is essential for cell growth, enzyme plays a role in tumor generation Homo sapiens ADP + O-phosphocholine
-
 ?

Subunits

Subunits Comment Organism
oligomer mainly dimers and tetramers, x * 50000 Homo sapiens
oligomer subtype alpha, mainly dimers and tetramers, x * 50000-52000 Mus musculus
oligomer subtype beta, mainly dimers and tetramers, x * 42000 Mus musculus

Synonyms

Synonyms Comment Organism
More two subtypes identified which are named alpha and beta (ChoKalpha and ChoKbeta), alpha subtype displays two splicing variants names alpha1 and alpha2 Mus musculus