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Literature summary for 2.7.1.36 extracted from

  • Gray, J.C.; Kekwick, R.G.O.
    Mevalonate kinase in green leaves and etiolated cotyledons of the french bean Phaseolus vulgaris (1973), Biochem. J., 133, 335-347.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
iodoacetamide 10 mM, 20% activation Phaseolus vulgaris

Inhibitors

Inhibitors Comment Organism Structure
ADP very weak inhibition Phaseolus vulgaris
CuSO4 10 mM, almost complete inhibition Phaseolus vulgaris
farnesyl diphosphate 0.3 mM, approx. 75% inhibition Phaseolus vulgaris
geranyl diphosphate 0.3 mM, approx. 10% inhibition Phaseolus vulgaris
geranylgeranyl diphosphate 0.3 mM, approx. 90% inhibition Phaseolus vulgaris
mevalonate at high concentrations Phaseolus vulgaris
mevalonate 5-phosphate 0.3 mM, approx. 45% inhibition Phaseolus vulgaris
Mn2+ inhibition at high concentrations Phaseolus vulgaris
p-chloromercuribenzoate 1 mM, almost complete inhibition Phaseolus vulgaris
phytyl diphosphate 0.3 mM, almost complete inhibition Phaseolus vulgaris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0426
-
RS-mevalonate pH 7.0, 30°C, enzyme from etiolated cotyledons Phaseolus vulgaris
0.046
-
RS-mevalonate pH 7.0, 30°C, leaf enzyme Phaseolus vulgaris
1.54
-
ATP pH 7.0, 30°C, enzyme from etiolated cotyledons Phaseolus vulgaris
1.75
-
ATP pH 7.0, 30°C, enzyme fom green leaves Phaseolus vulgaris
2
-
ATP pH 7.0, 30°C Phaseolus vulgaris

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ maximal activity at 9 mM Phaseolus vulgaris
Mn2+ most active at low concentrations Phaseolus vulgaris
Mn2+ maximal activation at 2 mM Phaseolus vulgaris

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
97000 104000 gel filtration Phaseolus vulgaris

Organism

Organism UniProt Comment Textmining
Phaseolus vulgaris
-
-
-

Purification (Commentary)

Purification (Comment) Organism
enzyme from cotyledons and leaves, ammonium sulfate, Sephadex G-200, DEAE-Sephadex Phaseolus vulgaris

Source Tissue

Source Tissue Comment Organism Textmining
cotyledon etiolated Phaseolus vulgaris
-
leaf
-
Phaseolus vulgaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + mevalonate
-
Phaseolus vulgaris ?
-
?
ATP + mevalonate
-
Phaseolus vulgaris ADP + phosphomevalonate
-
?
CTP + mevalonate weak activity Phaseolus vulgaris CDP + phosphomevalonate
-
?
GTP + mevalonate weak activity Phaseolus vulgaris GDP + phosphomevalonate
-
?
ITP + mevalonate
-
Phaseolus vulgaris IDP + phosphomevalonate
-
?
UTP + mevalonate
-
Phaseolus vulgaris UDP + phosphomevalonate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7.5
-
Phaseolus vulgaris

pH Range

pH Minimum pH Maximum Comment Organism
5.5 9 approx. 30% of maximal activity at pH 5.5, approx. 60% of maximal activity at pH 9 Phaseolus vulgaris