Cloned (Comment) | Organism |
---|---|
expression of wild-type and N301T mutant mevalonate kinase in COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A148T | mutation may be responsible for the hyperimmunoglobulinemia phenotype | Homo sapiens |
H20P | markedly decreased mevalonate kinase activity when expressed in Escherichia coli | Homo sapiens |
I268T | markedly decreased mevalonate kinase activity when expressed in Escherichia coli | Homo sapiens |
L264F | markedly decreased mevalonate kinase activity when expressed in Escherichia coli | Homo sapiens |
L265P | markedly decreased mevalonate kinase activity when expressed in Escherichia coli | Homo sapiens |
N301T | 5-20% of wild-type activity | Homo sapiens |
P165L | mutation may be responsible for the hyperimmunoglobulinemia phenotype | Homo sapiens |
T243I | markedly decreased mevalonate kinase activity when expressed in Escherichia coli | Homo sapiens |
V310M | markedly decreased mevalonate kinase activity when expressed in Escherichia coli | Homo sapiens |
V377I | mutation may be responsible for the hyperimmunoglobulinemia phenotype | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
farnesyl diphosphate | - |
Rattus norvegicus | |
farnesyl diphosphate | - |
Sus scrofa | |
geranyl diphosphate | - |
Homo sapiens | |
geranyl diphosphate | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.019 | - |
(RS)mevalonate | liver mevalonate kinase | Sus scrofa | |
0.069 | - |
(RS)mevalonate | - |
Methanocaldococcus jannaschii | |
0.069 | - |
(RS)mevalonate | recombinant mevalonate kinase | Sus scrofa | |
0.092 | - |
ATP | recombinant mevalonate kinase | Sus scrofa | |
0.27 | - |
(RS)mevalonate | liver mevalonate kinase | Rattus norvegicus | |
0.3 | - |
ATP | liver mevalonate kinase | Sus scrofa | |
1.75 | - |
ATP | liver mevalonate kinase | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Sus scrofa | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
peroxisome | mevalonate kinase is predominantly localized in peroxisomes, but is easily solubilized and released into the cytosol | Rattus norvegicus | 5777 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
41990 | - |
2 * 41990, deduced from nucleotide sequence | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q03426 | mevalonate kinase deficiency causes mevalonic aciduria, hyperimmunoglobuinemia D and periodic fever syndrome | - |
Methanocaldococcus jannaschii | - |
- |
- |
Rattus norvegicus | P17256 | - |
- |
Sus scrofa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + mevalonate | - |
Methanocaldococcus jannaschii | ADP + phosphomevalonate | - |
? | |
ATP + mevalonate | - |
Rattus norvegicus | ADP + phosphomevalonate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Sus scrofa |
dimer | - |
Methanocaldococcus jannaschii |
dimer | 2 * 41990, deduced from nucleotide sequence | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
farnesyl diphosphate | liver mevalonate kinase | Sus scrofa | |
0.002 | - |
geranyl diphosphate | liver mevalonate kinase | Sus scrofa | |
0.0025 | - |
farnesyl diphosphate | - |
Rattus norvegicus | |
0.116 | - |
geranyl diphosphate | - |
Homo sapiens |