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Literature summary for 2.7.1.36 extracted from
- Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism (2007), Biochem. Biophys. Res. Commun., 355, 359-364.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| atorvastatin | besides increases in mRNA level of HMG CoA reductase, treatment increases hepatic mRNA levels of both mevalonate kinase and cob(I)alamin adenosyltransferase | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| heart | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| liver | highest expression of both mevalonate kinase and cob(I)alamin adenosyltransferase | Mus musculus | - |
| liver | highest expression of both mevalonate kinase and cob(I)alamin adenosyltransferase | Homo sapiens | - |
| additional information | mevalonate kinase and cob(I)alamin adenosyltransferase display a similar tissue expression pattern. Their genes are located in a head-to-head formation and are suppressed by an excess of cholesterol as well as sterol regulatory element binding protein SREBP-2 | Mus musculus | - |
| additional information | mevalonate kinase and cob(I)alamin adenosyltransferase display a similar tissue expression pattern. Their genes are located in a head-to-head formation and are suppressed by an excess of cholesterol as well as sterol regulatory element binding protein SREBP-2 | Homo sapiens | - |
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